1013-77-0 Usage
General Description
1-(2,4-dimethylphenyl)piperazinehydrochloride, also known as 2,4-DMPH, is a chemical compound that belongs to the class of piperazine derivatives. It is commonly used as a research chemical and has been investigated for its potential pharmacological properties. 2,4-DMPH is a psychoactive substance that has stimulant and hallucinogenic effects. It acts as a serotonin receptor agonist and is known to produce altered states of consciousness. The hydrochloride salt form of this compound is often used for ease of handling and storage. However, 2,4-DMPH is not approved for medical use and its consumption can be dangerous and potentially harmful.
Check Digit Verification of cas no
The CAS Registry Mumber 1013-77-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,1 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1013-77:
(6*1)+(5*0)+(4*1)+(3*3)+(2*7)+(1*7)=40
40 % 10 = 0
So 1013-77-0 is a valid CAS Registry Number.
1013-77-0Relevant articles and documents
Discovery of aroyl piperazine derivatives as IKr & I Ks dual inhibitors for cardiac arrhythmia treatment
Guo, Xiaoke,Sun, Haopeng,Du, Lvpei,Huang, Lu,Xu, Jing,Zhu, Yingying,Yu, Peng,Zhang, Xiaojin,Tang, Yiqun,You, Qidong
, p. 497 - 505 (2014/06/23)
Combined blockade of IKr and IKs potassium channels is considered to be a promising therapeutic strategy for arrhythmia. In this study, we designed and synthesized 15 derivatives through modifying the hit compound 7 that was discovered by screening in-house database by whole-patch clamp technique. All of the compounds were evaluated on CHO and HEK 293 cell lines stably expressing hERG (IKr) and hKCNQ1/KCNE1 (IKs) potassium channels, and half of them exhibited improved dual IKr and IKs inhibitory effects compared to the hit compound. Compounds 7a and 7b with potent dual inhibitory activities were selected for further in vivo evaluations. Due to the preferable pharmacological behaviors, compound 7a deserved further optimization as a promising lead compound.
