10130-24-2Relevant academic research and scientific papers
Near room temperature cross-coupling reactions of arene boronic acids with a quinoxaline 1,4-dioxide benzylsulfanyl derivative
Dahbi, Samir,Bisseret, Philippe
supporting information; experimental part, p. 3759 - 3763 (2012/09/25)
A new quinoxaline 1,4-dioxide benzylsulfanyl derivative was tested under mild conditions in copper-mediated Liebeskind-Srogl (LS) cross-coupling reactions with arene boronic acids. These first organometallic cross-coupling reactions performed on a quinoxaline 1,4-dioxide derivative open new perspectives in medicinal chemistry. They represent also the first LS cross-couplings run with an electrophile equipped with an aryl N-oxide moiety. A mild an efficient protocol was developed to prepare quinoxaline 1,4-dioxide derivatives. A benzylsulfanyl quinoxaline 1,4-dioxide derivative was engaged as an electrophilic partner in copper-mediated Liebeskind-Srogl cross-coupling reactions with a wide range of arene boronic acids. These experiments represent the first organometallic coupling reactions on quinoxaline 1,4-dioxide derivatives. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
