1013032-15-9Relevant articles and documents
T-type calcium channel blockers: Spiro-piperidine azetidines and azetidinones - Optimization, design and synthesis
Smith, Elizabeth M.,Sorota, Steve,Kim, Hyunjin M.,McKittrick, Brian A.,Nechuta, Terry L.,Bennett, Chad,Knutson, Chad,Burnett, Duane A.,Kieselgof, Jane,Tan, Zheng,Rindgen, Diane,Bridal, Terry,Zhou, Xiaoping,Jia, Yu-Ping,Dong, Zoe,Mullins, Debbie,Zhang, Xiaoping,Priestley, Tony,Correll, Craig C.,Tulshian, Deen,Czarniecki, Michael,Greenlee, William J.
scheme or table, p. 4602 - 4606 (2010/10/02)
A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (CaV3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. Confirmation and