1013033-83-4Relevant articles and documents
Spiro-piperidine azetidinones as potent TRPV1 antagonists
Xiao, Dong,Palani, Anandan,Aslanian, Robert,McKittrick, Brian A.,McPhail, Andrew T.,Correll, Craig C.,Phelps, P. Tara,Anthes, John C.,Rindgen, Diane
scheme or table, p. 783 - 787 (2009/08/15)
A series of spiro-piperidine azetidinone were synthesized and evaluated as potential TRPV1 antagonists. An important issue of plasma stability was investigated and resolved. Further focused SAR study lead to the discovery of a potent antagonist with good
TREATING PAIN, DIABETES, AND DISORDERS OF LIPID METABOLISM
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Page/Page column 85; 90, (2008/06/13)
Disclosed is a method of treating a disease or condition (e.g., pain, diabetes or disorders of lipid metabolism) comprising administering an azetidine derivative of the formula I selected from the group consisting of the compounds defined by Tables 1, 2,