1013088-41-9Relevant articles and documents
Enantioselective synthesis of α-fluorinated β2-amino acids
Edmonds, Michael K.,Graichen, Florian H.M.,Gardiner, James,Abell, Andrew D.
, p. 885 - 887 (2008)
A methodology for the enantioselective synthesis of α-fluorinated β2-amino acids has been developed from readily available carboxylic acids 3. Conversion to the Evan's oxazolidinone followed by enantioselective fluorination and alkylation gave 7 in high diastereomeric excess (>95%). Subsequent removal of the oxazolidinone and amination at the Bn-protected hydroxyl center gave optically active α-fluorinated β2-amino acids.