101323-79-9Relevant academic research and scientific papers
Thieno Compounds. Part 5: Basically Substituted Thienopyrimidines
Boehm, R.,Pech, R.,Haubold, Gudrun,Hannig, E.
, p. 23 - 25 (2007/10/02)
Derivatives of Thienopyrimidine are the analogous structures of quinazolines, which are used in therapy, especially against hypertonia.Some new basically substituted thienopyrimidines were synthesized from 3,4-dihydro-4-oxothienopyrimidines with 4-chlorothienopyrimidines as intermediates.The corresponding 2,4-dibasic derivatives were received in the same way by transformation of the 1,2,3,4-tetrahydro-2,4-dioxothienopyrimidines.Derivatives with two different basic groups were obtained by a step-wise substitution of the both chlorine-atoms.I the case of a reaction with an aliphatic amine to substitute the chlorine in position 4 followed by a reaction with an aromatic amine both the chlorine in position 2 and the basic group in position 4 are replaced.
