101348-86-1Relevant academic research and scientific papers
Mimics of Transaminase Enzymes
Breslow, R.,Czarnik, A. W.,Lauer, M.,Leppkes, R.,Winkler, J.,Zimmerman, S.
, p. 1969 - 1979 (2007/10/02)
Pyridoxamine has been attached to the primary side and to the secondary side of β-cyclodextrin; the resulting compounds convert α-keto acids to amino acids with substrate selectivity and some stereoselectivity.Pyridoxamine has also been attached to a synthetic macrocycle; the attached binding group showed substrate selectivity.Chains carrying catalytic basic groups have been attached to pyridoxamine; appropriate systems catalyze the prototropic rearrangement characteristic of transamination.A catalyzed HCl elimination involving chloropyruvic acid was observed.A tetrahydroquinoline system related to pyridoxamine was synthesized to permit the stereochemically defined placement of a basis catalytic group.This converted keto acids to amino acids with good stereoselectivity for the formation of optically active products.
MODIFICATIONS OF HYDROPHOBIC CAVITY AND THEIR EFFECTS ON THE COMPLEX FORMATION WITH A HIDROPHOBIC SUBSTRATE
Soga, Tsunehiko,Odashima, Kazunori,Koga, Kenji
, p. 4351 - 4354 (2007/10/02)
The derivatives of CP44 (1a) were designed and synthetized to modify the natures of its hydrophobic cavity, and the effects on the complex formation with a hydrophobic substrate in aqueous solution were examined.
