10135-23-6

Basic information

• Product Name: 1-PHENETHYL-PYRROLIDIN-2-ONE
• Synonyms: 1-PHENETHYL-PYRROLIDIN-2-ONE;1-(2-Phenylethyl)pyrrolidin-2-one;2-Pyrrolidinone,1-(2-phenylethyl)-
• CAS NO: 10135-23-6
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.2536
• Mol File: 10135-23-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 350.5°C at 760 mmHg
• Flash Point: 144.2°C
• Appearance: /
• Density: 1.084g/cm³
• Vapor Pressure: 4.39E-05mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-PHENETHYL-PYRROLIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENETHYL-PYRROLIDIN-2-ONE(10135-23-6)
• EPA Substance Registry System: 1-PHENETHYL-PYRROLIDIN-2-ONE(10135-23-6)

Safety Data

• Hazardous Substances Data: 10135-23-6(Hazardous Substances Data)

Usage

General Description

1-Phenethyl-pyrrolidin-2-one is a chemical compound that falls under the category of organic compounds and widely used in chemical research. It is characterized by a unique structure that includes a fused pyrrolidin-2-one ring merged with a phenethyl moiety. It is a member of lactams group? and phenethylamines. Known for its reactivity, this chemical is often used as a precursor or a substrate in various chemical reactions. Further research can reveal more specific applications in various industries including but not limited to pharmaceutical, biotechnology, and chemical industries. However, as with all chemicals, proper handling and usage are necessary to ensure safety.

InChI:InChI=1/C12H15NO/c14-12-7-4-9-13(12)10-8-11-5-2-1-3-6-11/h1-3,5-6H,4,7-10H2

Upstream product

• 201230-82-2 carbon monoxide 
• 5263-58-1 N-allylphenethylamine 
• 19883-35-3 (Z)-N-(2-phenylethenyl)-2-pyrrolidinone 
• 6908-67-4 (E)-1-(2-phenylethenyl)-2-pyrrolidinone 
• 64-04-0 phenethylamine 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 591-50-4 iodobenzene 
• 616-45-5 2-pyrrolidinon 
• 103-63-9 1-phenyl-2-bromoethane 
• 189809-02-7 1-(tosylmethyl)-2-pyrrolidinone 
• 100-39-0 benzyl bromide 
• 105522-45-0 4-chloro-N-(2-phenylethyl)butanamide 
• 189809-26-5 1-(1-tosyl-2-phenylethyl)-2-pyrrolidinone 

Downstream Products

• 234-92-4 pyrrolo[2,1-a]isoquinoline 
• 60737-55-5 (E)-1-phenethyl-2-(nitromethylene)pyrrolidine 
• 1453096-90-6 1-[2-(4-iodophenyl)ethyl]pyrrolidin-2-one 

Relevant articles and documents

INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION

Compounds of Formula (I) and methods of inhibiting the replication of viruses in a biological sample or patient, of reducing the amount of viruses in a biological sample or patient, and of treating a virus infection in a patient, comprising administering to said biological sample or patient an effective amount of a compound represented by Formula (I), a compound of Table A or B or a pharmaceutically acceptable salt thereof.

Practical Intermolecular Hydroarylation of Diverse Alkenes via Reductive Heck Coupling

The hydroarylation of alkenes is an attractive approach to construct carbon-carbon (C-C) bonds from abundant and structurally diverse starting materials. Herein we report a palladium-catalyzed reductive Heck hydroarylation of aliphatic and heteroatom-substituted terminal alkenes and select internal alkenes with an array of (hetero)aryl iodides. The reaction is anti-Markovnikov selective with terminal alkenes and tolerates a wide variety of functional groups on both the alkene and (hetero)aryl coupling partners. Additionally, applications of this method to complex molecule diversifications are demonstrated. Mechanistic experiments are consistent with a mechanism in which the key alkylpalladium(II) intermediate is intercepted with formate and undergoes a decarboxylation/C-H reductive elimination cascade to afford the saturated product and turn over the cycle.

BIVALENT AMPA RECEPTOR POSITIVE ALLOSTERIC MODULATORS

Embodiments of the invention are directed to compounds that are positive allosteric modulators of AMP A receptors.