1013544-47-2Relevant academic research and scientific papers
Novel four-step synthesis of thioxo-quinazolino[3,4- A ]quinazolinone derivatives
Shafii, Behnaz,Saeedi, Mina,Mahdavi, Mohammad,Foroumadi, Alireza,Shafiee, Abbas
, p. 215 - 221 (2014)
A novel synthesis of thioxo-quinazolino[3,4-a]quinazolinone framework was developed through a four-step reaction starting from isatoic anhydride. The resulting 2-aminobenzamides from the reaction of isatoic anhydride and different amines underwent coupling-cyclization reaction with 2-nitrobenzaldehydes, reduction of nitro group, and then cyclization reaction with carbon disulfide (CS2). All steps were carried out under easy and user-friendly conditions in a short time without using expensive catalysts or reagents. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
