1013643-09-8Relevant articles and documents
Design, synthesis, and evaluation of the anticancer activity of 2-amino-aryl-7-aryl-benzoxazole compounds
Khajondetchairit, Patcharaporn,Phuangsawai, Oraphan,Suphakun, Praphasri,Rattanabunyong, Siriruk,Choowongkomon, Kiattawee,Gleeson, Matthew Paul
, p. 987 - 994 (2017)
A series of 2-amino-aryl-7-aryl-benzoxazole derivatives have been designed, synthesized, and evaluated as anticancer agents. Fourteen of the compounds exhibited cytotoxic effects toward human A549 lung cancer cells. We found 12l was the most potent with a
2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors
Costales, Abran,Mathur, Michelle,Ramurthy, Savithri,Lan, Jiong,Subramanian, Sharadha,Jain, Rama,Atallah, Gordana,Setti, Lina,Lindvall, Mika,Appleton, Brent A.,Ornelas, Elizabeth,Feucht, Paul,Warne, Bob,Doyle, Laura,Basham, Stephen E.,Aronchik, Ida,Jefferson, Anne B.,Shafer, Cynthia M.
supporting information, p. 1592 - 1596 (2014/03/21)
2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of improving in vitro and target modulation potency and physicochemical properties.
2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors
Gerspacher, Marc,Furet, Pascal,Pissot-Soldermann, Carole,Gaul, Christoph,Holzer, Philipp,Vangrevelinghe, Eric,Lang, Marc,Erdmann, Dirk,Radimerski, Thomas,Regnier, Catherine H.,Chene, Patrick,Pover, Alain De,Hofmann, Francesco,Baffert, Fabienne,Buhl, Thomas,Aichholz, Reiner,Blasco, Francesca,Endres, Ralf,Trappe, J?rg,Drueckes, Peter
scheme or table, p. 1724 - 1727 (2010/07/03)
A series of novel benzoxazole derivatives has been designed and shown to exhibit attractive JAK2 inhibitory profiles in biochemical and cellular assays, capable of delivering compounds with favorable PK properties in rats. Synthesis and structure-activity relationship data are also provided.
