101366-51-2 Usage
Description
4'-METHYL[1,1'-BIPHENYL]-4-SULFONYL CHLORIDE, also known as 4-methylbiphenyl-4-sulfonyl chloride, is a chemical compound characterized by the molecular formula C13H11ClO2S. It is a sulfonating agent that plays a significant role in the chemical synthesis of pharmaceuticals and agrochemicals. This colorless to pale yellow liquid, with a strong, pungent odor, is typically handled and stored under inert gas to prevent oxidation and degradation. As an important building block, it is instrumental in the production of various pharmaceutical and agrochemical products.
Uses
Used in Pharmaceutical Industry:
4'-METHYL[1,1'-BIPHENYL]-4-SULFONYL CHLORIDE is used as a sulfonating agent for the synthesis of pharmaceutical compounds. It introduces sulfonate groups into organic molecules, which is crucial for the development of drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4'-METHYL[1,1'-BIPHENYL]-4-SULFONYL CHLORIDE is utilized as a reagent in the synthesis of agrochemicals. Its ability to introduce sulfonate groups aids in the creation of compounds with targeted pesticidal or herbicidal activities.
Used in Organic Synthesis:
4'-METHYL[1,1'-BIPHENYL]-4-SULFONYL CHLORIDE is employed as a reagent in organic synthesis to introduce sulfonate groups into various organic molecules. This functionality is essential for the development of new organic compounds with specific chemical properties and potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 101366-51-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,3,6 and 6 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 101366-51:
(8*1)+(7*0)+(6*1)+(5*3)+(4*6)+(3*6)+(2*5)+(1*1)=82
82 % 10 = 2
So 101366-51-2 is a valid CAS Registry Number.
101366-51-2Relevant articles and documents
Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13
Monovich, Lauren G.,Tommasi, Ruben A.,Fujimoto, Roger A.,Blancuzzi, Vincent,Clark, Kirk,Cornell, Wendy D.,Doti, Robert,Doughty, John,Fang, James,Farley, David,Fitt, John,Ganu, Vishwas,Goldberg, Ronald,Goldstein, Robert,Lavoie, Stacey,Kulathila, Raviraj,Macchia, William,Parker, David T.,Melton, Richard,O'Byrne, Elizabeth,Pastor, Gary,Pellas, Theodore,Quadros, Elizabeth,Reel, Noela,Roland, Dennis M.,Sakane, Yumi,Singh, Hem,Skiles, Jerry,Somers, Joseph,Toscano, Karen,Wigg, Andrew,Zhou, Siyuan,Zhu, Lijuan,Shieh, Wen-Chung,Xue, Song,McQuire, Leslie W.
supporting information; experimental part, p. 3523 - 3538 (2010/03/30)
The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). An effective MMP-13 inhibitor would therefore be a novel disease modifying therapy for the treatment of arthritis. Our efforts have resulted in the discovery of a series of carboxylic acid inhibitors of MMP-13 that do not significantly inhibit the related MMP-1 (collagenase-1) or tumor necrosis factor-α (TNF-α) converting enzyme (TACE). It has previously been suggested (but not proven) that inhibition of the latter two enzymes could lead to side effects. A promising carboxylic acid lead 9 was identified and a convergent synthesis developed. This paper describes the optimization of 9 and the identification of a compound 24f for further development. Compound 24f is a subnanomolar inhibitor of MMP-13 (IC50 value 0.5 nM and Ki of 0.19 nM) having no activity against MMP-1 or TACE (IC50 of >10000 nM). Furthermore, in a rat model of MMP-13-induced cartilage degradation, 24f significantly reduced proteoglycan release following oral dosing at 30 mg/kg (75% inhibition, p 0.05) and at 10 mg/kg (40% inhibition, p 0.05).
