10138-99-5 Usage
General Description
(2S)-2-Amino-3-dimethylaminopropanoic acid, also known as α-methylserine, is a non-proteinogenic amino acid that contains both an amino group and a carboxylic acid group. It is classified as a neutral, hydrophobic amino acid and is commonly found in proteins, where it plays a role in the structure and function of the protein. α-methylserine has been studied for its potential therapeutic applications, including as an antimicrobial and antiviral agent, as well as for its potential role in the treatment of neurological disorders. It is also used as a chiral building block in organic synthesis. However, more research is needed to fully understand the properties and potential uses of this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 10138-99-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,3 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 10138-99:
(7*1)+(6*0)+(5*1)+(4*3)+(3*8)+(2*9)+(1*9)=75
75 % 10 = 5
So 10138-99-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H12N2O2/c1-7(2)3-4(6)5(8)9/h4H,3,6H2,1-2H3,(H,8,9)/t4-/m0/s1
10138-99-5Relevant articles and documents
ASYMMERTIC SYNTHESIS OF Β-SUBSTITUTED α-AMINO ACIDS VIA A CHIRAL Ni(II) COMPLEX OF DEHYDROALANINE
Belokon, , Yuri N.,Sagyan, Ashot S.,Djamgaryan, Silva M.,Bakhmutov, Vladimir I.,Belikov, Vasili M.
, p. 5507 - 5514 (2007/10/02)
An efficient approach to the asymmetric synthesis of β-substituted (S)-alanines is describen.The chiral Ni(II) complex of a Schiff base derived from (S)-o-N-(N-benzylpropyl)aminobenzophenone (BBP) and glycine was treated with formaldehyde and sodium methoxide to give a corresponding (R)-serine complex which, in turn, was converted to the chiral Ni(II) dehydroalanine complex.Michael type base catalyzed addition of nucleophiles (including MeOH, Me2NH, PhCH2NH2, imidazole, PhSH, PhCH2SH,, malonic ester and benzylmagnesium chloride) produced a mixture of diastereoisomeric complexes with a 70-90percent excess of S,S (or L,L) isomers over the S,R (or L,D) ones.The cleavage of pure diastereoisomers with aqueous HCl gave, in good yields, β-substituted (S) (or L)-alanines and regenerated the chiral auxiliary (BBP).