1014-99-9

Usage

Uses

Used in Organic Chemistry:
Alpha, Alpha'-Dithiocyanato-p-Xylene is used as a reagent in organic chemistry for its ability to bind tightly with metals, facilitating a variety of chemical reactions.
Used in Metal Reactions:
In the field of metal chemistry, DTDPX is employed as a reagent to bind with metals, enabling specific reactions that are crucial for the synthesis of various compounds.
Used in Synthesis Processes:
Due to its volatility, Alpha, Alpha'-Dithiocyanato-p-Xylene is used in synthesis processes where the transformation of the compound into a gaseous form is necessary for the reaction to proceed.
Safety Measures:
When handling Alpha, Alpha'-Dithiocyanato-p-Xylene, it is imperative to follow proper safety protocols to mitigate the risks associated with its potentially hazardous nature.

InChI:InChI=1/C10H8N2S2/c11-7-13-5-9-1-2-10(4-3-9)6-14-8-12/h1-4H,5-6H2

Upstream product

• 463-71-8 thiophosgene 
• 51964-30-8 1,4-bis(aminomethyl)benzene dihydrochloride 

Downstream Products

• 291762-88-4 2-(4-isithiocyanatomethyl-benzyl)-3-methyl-6-octyl-5H,7H-2a-thia(2a-S^IV)-2,3,4a,7a-tetraazacyclopenta[cd]-indene-1,4(2H,3H)-dithione 
• 291762-90-8 2,3-bis(4-isithiocyanatomethyl-benzyl)-6-octyl-5H,7H-2a-thia(2a-S^IV)-2,3,4a,7a-tetraazacyclopenta[cd]-indene-1,4(2H,3H)-dithione 
• 291762-86-2 C₄₄H₆₀N₈S₆ 
• 442636-24-0 C₅₀H₅₆N₈O₂S₆ 
• 329771-56-4 1,4-bis[3-[3-(aminomethyl)benzyl]thioureidomethyl]benzene 
• 329771-55-3 1,4-bis[3-[3-(tert-butoxycarbonylaminomethyl)benzyl]thioureidomethyl]benzene 
• 150367-66-1 2,3-bis<(p-isothiocyanatomethylphenyl)methyl>-6,7-dihydro-5H-2a-thia(2a-S^IV)-2,3,4a,7a-tetraazacyclopentindene-1,4(2H,3H)-dithione 

Relevant academic research and scientific papers

NSCLC structure-activity relationship (sar) study of diisothiocyanates for antiproliferative activity on A549 Human non-small cell lung carcinoma (NSCLC)

Isothiocyanate functional group (-N=C=S) is widely accepted as an important moiety for anti-cancer effects of naturally occurring isothiocyanate compounds (ITCs). Herein, a series of diisothiocyanate (diITCs) derivatives were synthesized and evaluated in antiproliferative assays on A549 human non-small cell lung cancer and IMR90 human foetal lung cell lines for structure-activity relationship (SAR) and cancer cell selectivity studies. Results showed that aliphatic and benzylic diITCs were more cytotoxic to A549 cells than natural ITCs; benzyl isothiocyanate (BITC) and phenyl isothiocyanate (PITC), and a currently available anticancer drug; etoposide. Aromatic diITCs were not as active. Notably, most of the diITCs reported in this work were significantly more selective than etoposide to inhibit proliferation of the cancer cells (A549) over the normal cells (IMR90). This study demonstrated a guideline to modify chemical structures of diITCs for anti-NSCLC agents.

ISOTHIOCYANATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.

ISOTHIOCYANATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.