101403-23-0Relevant articles and documents
Structure-Activity Relationships of Dopaminergic 5-Hydroxy-2-aminotetralin Derivatives with Functionalized N-Alkyl Substituents
Seiler, Max P.,Stoll, Andre P.,Closse, Annemarie,Frick, Willy,Jaton, Annelise,Vigouret, Jean-Marie
, p. 912 - 917 (1986)
5-Hydroxy-2-aminotetralin derivatives in which one N-alkyl substituent carries a functional group have been prepared and their dopaminergic activities compared with those of 5-hydroxy-2-(di-n-propylamino)tetralin (5-OH-DPAT) and known ergolines.Several members of the series demonstrated high affinities in dopamine (DA) receptor binding and DA agonist properties in the rotational behavior model in the range of known potent ergolines.The results suggests that the accessory binding site for the larger N-alkyl substituent of the 5-hydroxy-2-aminotetralins can accommodate various neutral and bulky functionalities and is probably identical with the site(s) to which the 8-substituents of the ergolines bind.
Derivatives of (R)-2-amino-5-methoxytetralin: Antagonists and Inverse Agonists at the Dopamine D2A Receptor
Hoeoek, Berit Backlund,Brege, Cecilia,Linnanen, Tero,Mikaels, Aesa,Malmberg, Aesa,Johansson, Anette M.
, p. 2167 - 2172 (2007/10/03)
A series of N-arylmethyl substituted (R)-5-methoxy-2-(propylamino)tetralins has been prepared and evaluated for affinity and efficacy at dopamine (DA) D2A receptors. The novel compounds appeared to be antagonists or inverse agonists. (R)-2-(Be
