101460-64-4Relevant academic research and scientific papers
Potential Antipsychotic Agents. 5. Synthesis and Antidopaminergic Properties of Substituted 5,6-Dimethoxysalicylamides and Related Compounds
Hoegberg, Thomas,Bengtsson, Stefan,Paulis, Tomas de,Johansson, Lars,Stroem, Peter,et al.
, p. 1155 - 1163 (2007/10/02)
A series of 3-substituted 5,6-dimethoxysalicylamides III (9-13 and 15) has been synthesized from the corresponding 2,5,6-trimethoxybenzoic acids.Relaxation times T1 and carbon chemical shifts of the methoxy groups in III showed that the 6-metho
Secondary β-Aminobenzamide and Heteroatom Directed Lithiation in the Synthesis of 5,6-Dimethoxyanthanilamides and Related Compounds
Bengtsson, Stefan,Hoegberg, Thomas
, p. 4549 - 4553 (2007/10/02)
Directed ortho-lithiation strategies have been applied in the synthesis of the dopamine D-2 antagonist (S)-6-amino-5-bromo-2,3-dimethoxy-N-benzamide (NCQ 318).The secondary β-amino side chain was found to be a powerful orth
