1014631-58-3Relevant articles and documents
A 1 - (2 - pyridyl) - pyrazole -3 - formic acid and synthetic method of derivative thereof (by machine translation)
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Paragraph 0075-0080; 0093-0110, (2019/03/06)
This application discloses a 1 - (2 - pyridyl) - pyrazole - 3 - carboxylic acid and its derivative synthesis method, which belongs to the field of organic synthesis. The 1 - (2 - pyridyl) - pyrazole - 3 - carboxylic acid and its derivative synthesis method comprises the following steps: a) in the presence of catalyst, containing 3, 5 - pyrazole dicarboxylic acid with the pyridine and/or pyridine derivatives in the reaction in a solution of the raw material, the catalyst comprises a copper salt; b) adding metal ion scavenger to remove the coordination of copper, to obtain 1 - (2 - pyridyl) - pyrazole - 3 - carboxylic acid and/or its derivatives. According to the methods of the invention by the 3, 5 - pyrazole dicarboxylic acid with the pyridine and/or pyridine derivatives in the air one-step synthesis of the target product, synthetic step is simple, the production cost is low, and the raw material safety and environmental protection. In addition, the method also has the efficiency at the same time with a higher yield, yield of the target product can be as high as 53%. (by machine translation)