101469-91-4

Basic information

• Product Name: N-Benzyl-(3S)-hydroxysuccinimide
• Synonyms: (3S)-N-Benzyl-3-hydroxypyrrolidine-2,5-dione;N-Benzyl-(3S)-hydroxysuccinimide;N-Benzyl-(S)-malimide;(S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione;(S)-1-benzyl-3-hydro×ypyrrolidine-2,5-dione;(R)-benzyl 3-fluoropyrrolidine-1-carboxylate
• CAS NO: 101469-91-4
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.20994
• EINECS: -0
• Mol File: 101469-91-4.mol
• Article Data: 19

Chemical Properties

• Melting Point: 110-111℃
• Appearance: /
• Density: 1.385
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Benzyl-(3S)-hydroxysuccinimide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-(3S)-hydroxysuccinimide(101469-91-4)
• EPA Substance Registry System: N-Benzyl-(3S)-hydroxysuccinimide(101469-91-4)

Safety Data

• Hazardous Substances Data: 101469-91-4(Hazardous Substances Data)

Usage

General Description

N-Benzyl-(3S)-hydroxysuccinimide, also known as NBS, is a well-known amine-reactive chemical frequently utilized in organic synthesis and bioconjugation reactions. N-Benzyl-(3S)-hydroxysuccinimide is derived from succinimide and is functionalized with a benzyl group and a hydroxyl group at the 3S position. NBS is commonly used as a mild and selective reagent for the bromination of alcohols and amines, as well as for the introduction of the succinimido group onto amines during peptide synthesis. Its reactivity with amines and its mild reaction conditions have made NBS a versatile tool in the fields of organic chemistry and bioconjugation.

Upstream product

• 97-67-6 (S)-Malic acid 
• 100-46-9 benzylamine 
• 129823-21-8 (S)-4-acetoxy-1-benzyl-2,5-pyrrolidinedione 
• 173353-28-1 3-benzoyloxy-1-benzyl-2,5-pyrrolidinedione 
• 78027-57-3 (RS)-N-benzyl-3-hydroxypyrrolidine-2,5-dione 

Downstream Products

• 129823-21-8 (S)-4-acetoxy-1-benzyl-2,5-pyrrolidinedione 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 122536-94-1 (S)-3-hydroxypyrrolidine hydrochloride 
• 74880-19-6 C₁₂H₁₈N₂ 
• 74880-19-6 methyl-(2S,4R)-4-amino-1-benzylpyrrolidine 
• 1040731-98-3 C₁₈H₁₇NO₄ 
• 192987-90-9 (4S)-1-benzyl-4,5-dihydroxypyrrolidin-2-one 
• 104713-75-9 barnidipine 
• 101930-01-2 (S)-3-acetoacetoxy-1-benzylpyrrolidine 
• 104757-53-1 [14C]-Barnidipine hydrochloride 

Relevant articles and documents

Synthesis method of (S)-3-pyrrolidinol hydrochloride

The invention discloses a synthesis method of (S)-3-pyrrolidinol hydrochloride, which belongs to the field of drug synthesis, and comprises the following steps: dehydrating and amidating L-malic acidand benzylamine as raw materials to obtain (3S)-N-benzyl-3-hydroxypyrrolidine-2,5-diketone, and carrying out one-pot reduction, debenzylation and salification to synthesize (S)-3-pyrrolidinol hydrochloride. The method is short in synthetic route, simple to operate, high in yield, good in product purity and beneficial to industrial production.

COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY

Provided are indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which LRRK2 kinase is involved. Also provided are pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.

COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY

Disclosed are indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which LRRK2 kinase is involved. Also disclosed are pharmaceutical compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.