1014695-50-1Relevant articles and documents
Synthesis of 3H, 2H4 and 14C-SCH 417690 (Vicriviroc)
Hesk,Borges,Hendershot,Koharski,McNamara,Ren,Saluja,Truong,Voronin
, p. 190 - 196 (2016)
Vicriviroc or SCH 417690 is a potent and selective antagonist of the CCR5 receptor. CCR5 receptor antagonists have the potential for the treatment of HIV infections. Four distinct isotopically labelled forms of SCH 417690 were synthesized. Low specific activity [3H]SCH 417690 was prepared for a preliminary absorption, distribution, metabolism and excretion evaluation of the compound and [14C]SCH 417690 for more definitive absorption, distribution, metabolism and excretion work, including an absorption, metabolism and excretion study in man. In addition, high specific activity [3H]SCH 417690 was prepared for CCR5 receptor binding work and [2H4]SCH 417690 was prepared as an internal standard for a liquid chromatography-mass spectrometry bioanalytical method. The paper discusses the synthesis of four isotopically labelled forms of SCH 417690.
Synthetic method of 3-hydroxy desloratadine metabolite
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Paragraph 0010, (2019/07/01)
The invention discloses a synthetic method of 3-hydroxy desloratadine metabolite, belongs to the field of drug metabolism and provides a synthetic method, which is reasonable in technical design, highin operability and high in yield, which is suitable for
Deuterium-Substituted Pyridin- And Pyrimidin-2-yl-Methylamine Compounds
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Paragraph 0383; 0384, (2018/04/14)
Described are deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds of structural Formula (I), which are agonists of 5-hydroxytryptamine receptors. Also described are pharmaceutical compositions comprising the deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds, and methods of use thereof.