1014697-18-7Relevant academic research and scientific papers
New 5,5′-disubstituted BINAP derivatives: Syntheses and pressure and electronic effects in Rh asymmetric hydrogenation
Alame,Jahjah,Berthod,Lemaire,Meille,de Bellefon
, p. 205 - 212 (2007)
A library of 5,5′-disubstituted BINAP derivatives were synthesized in good yield from optically pure BINAP and evaluated for the Rh-catalyzed homogeneous asymmetric hydrogenation of (α)-acylaminoacrylate ester, with ee of up to 77% being obtained with the phenyl derivative. The enantiomeric excess variation was followed according to the groups introduced in the 5,5′-position of BINAP and for a range of pressure from 5 to 30 bar.
