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10147-12-3

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10147-12-3 Usage

General Description

9H-Purin-6-amine, 9-b-D-arabinofuranosyl-2-chloro- is a chemical compound that is an analogue of the antiviral drug Vidarabine. It is a purine nucleoside analog that is used in the treatment of herpes simplex and herpes zoster infections. 9H-Purin-6-amine, 9-b-D-arabinofuranosyl-2-chloro- works by interfering with the replication and transcription of viral DNA, ultimately inhibiting the spread of the virus. It is commonly administered intravenously or topically, and may be used in combination with other antiviral medications for maximum efficacy. 9H-Purin-6-amine, 9-b-D-arabinofuranosyl-2-chloro- has shown promise in managing viral infections and may have potential for further development in antiviral therapy.

Check Digit Verification of cas no

The CAS Registry Mumber 10147-12-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,4 and 7 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 10147-12:
(7*1)+(6*0)+(5*1)+(4*4)+(3*7)+(2*1)+(1*2)=53
53 % 10 = 3
So 10147-12-3 is a valid CAS Registry Number.

10147-12-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 9.β.-D-Arabinofuranosyl-2-chloroadenine

1.2 Other means of identification

Product number -
Other names Spiro[cyclopropane-1,3'-[1,2]methanodicyclopropa[cd,gh]pentalene]octahydro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10147-12-3 SDS

10147-12-3Downstream Products

10147-12-3Relevant articles and documents

Enzymatic Synthesis of Therapeutic Nucleosides using a Highly Versatile Purine Nucleoside 2’-DeoxyribosylTransferase from Trypanosoma brucei

Pérez, Elena,Sánchez-Murcia, Pedro A.,Jordaan, Justin,Blanco, María Dolores,Manche?o, José Miguel,Gago, Federico,Fernández-Lucas, Jesús

, p. 4406 - 4416 (2018/09/14)

The use of enzymes for the synthesis of nucleoside analogues offers several advantages over multistep chemical methods, including chemo-, regio- and stereoselectivity as well as milder reaction conditions. Herein, the production, characterization and utilization of a purine nucleoside 2’-deoxyribosyltransferase (PDT) from Trypanosoma brucei are reported. TbPDT is a dimer which displays not only excellent activity and stability over a broad range of temperatures (50–70 °C), pH (4–7) and ionic strength (0–500 mM NaCl) but also an unusual high stability under alkaline conditions (pH 8–10). TbPDT is shown to be proficient in the biosynthesis of numerous therapeutic nucleosides, including didanosine, vidarabine, cladribine, fludarabine and nelarabine. The structure-guided replacement of Val11 with either Ala or Ser resulted in variants with 2.8-fold greater activity. TbPDT was also covalently immobilized on glutaraldehyde-activated magnetic microspheres. MTbPDT3 was selected as the best derivative (4200 IU/g, activity recovery of 22 %), and could be easily recaptured and recycled for >25 reactions with negligible loss of activity. Finally, MTbPDT3 was successfully employed in the expedient synthesis of several nucleoside analogues. Taken together, our results support the notion that TbPDT has good potential as an industrial biocatalyst for the synthesis of a wide range of therapeutic nucleosides through an efficient and environmentally friendly methodology.

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