1014700-32-3

Basic information

• Product Name: C₂₃H₂₁N₃O₂
• CAS NO: 1014700-32-3
• Molecular Weight: 371.439
• Mol File: 1014700-32-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₁N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₁N₃O₂(1014700-32-3)
• EPA Substance Registry System: C₂₃H₂₁N₃O₂(1014700-32-3)

Safety Data

• Hazardous Substances Data: 1014700-32-3(Hazardous Substances Data)

Upstream product

• 608-07-1 2-(5-methoxyindol-3-yl)ethylamine 
• 257876-10-1 6-phenylnicotinoyl chloride 

Relevant articles and documents

Synthesis of benzamide derivatives as TRPV1 antagonists

From hit compounds identified by high throughput screening (HTS), we have found compound 1 as a lead TRPV1 antagonist and confirmed its potential as a treatment for pain. Compound 1 has led to potent TRPV1 antagonistic benzamide derivatives ((±)-2: human IC50 = 23 nM, (±)-3: human IC50 = 14 nM in the capsaicin-induced calcium influx assay) containing indole and naphthyl moieties, obtained by elaboration of the tryptamine scaffold or via bioisosteric replacements.