101488-78-2Relevant academic research and scientific papers
ALKALOIDS FROM Corydalis solida (L.) SW. MASS SPECTROMETRY OF QUARTERNARY BENZYLISOQUINOLINE ALKALOIDS
Slavik, Jiri,Dolejs, Ladislav,Slavikova, Leonora
, p. 2299 - 2309 (2007/10/02)
From the strongly polar fraction from the tubers of Corydalis solida (L.) SW., a new quarternary alkaloid, (+)-N-methyllaudanidinium iodide, was isolated after conversion to iodides.Mass spectrometric behaviour of this type of quarternary alkaloids is described.In the tubers (0.37percent of alkaloids) the main alkaloid component is (+)- and (+/-)-tetrahydropalmatine; other dominant alkaloids include protopine, (+)-corydaline, allocryptopine, dehydrocorydaline and jatrorrhyzine. (+/-)-Corybulbine, (+)-corypalmine, (-)-isocorypalmine, (-)-scoulerine, (-)-stylopine, corysamine, palmatine, (+)-methyllaudanidinium hydroxide, (-)-cis-N-methylcanadinium hydroxide and cis-N-methylstylopinium hydroxide represent minor alkaloids.The last three mentioned were isolated in form of iodides.Bulbocapnine, coptisine, berberine and columbamine were detected in trace amounts.The main alkaloid of the aerial parts of the plant (0.35percent of alkaloids) is berberine, accompanied by coptisine, (-)- and (+/-)-canadine, (-)-stylopine, isoboldine, protopine, columbamine and (-)-cis-N-methylcanadinium hydroxide (isolated in form of iodide) as significant components.Among minor alkaloids allocryptopine, (-)-isocorypalmine, (+)-corypalmine, (+/-)- and (-)-tetrahydropalmatine, corysamine, dehydrothalictricavine, palmatine and cis-N-methylstylopinium hydroxide (as iodide) were isolated and trace amounts of jatrorrhyzine and bulbocapnine were detected.
