101492-92-6Relevant articles and documents
A New Methodology to Key Intermediates for Synthesizing Polyene Compounds
Ma, Dawei,Lu, Xiyan
, p. 6319 - 6330 (2007/10/02)
ω-Alkoxy-(2E,4E)-dienoates, ω-oxo-(2E,4E)-dienoates and δ-oxo-α,β:γ,δ-dienones were prepared according to a new methodology shown in scheme I.High yield and high stereoselectivity were achieved by using transition metal catalyzed isomerization of ynoates or ynones instead of using Wittig-Horner-wadsworth-Emmons reaction to constitute the diene moiety.The usefulness of this methodology was demonstrated by the preparation of important synthetic precursors to polyene compounds and natural products such as 10--(2E,4E)-decadienoates, methyl 8--(2E,4E)-octadienoate, methyl 10-benzyloxy-(2E,4E)-decadienoate, 6-oxo-(2E,4E)-tetradecadienal, methyl 8-oxo-(2E,4E)-octadienoate, and retrofractamide A.
