1015064-87-5

Basic information

• Product Name: [4-(2,4-Dimethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3]pyrro-6-yl]-carbamic acid ethyl ester
• Synonyms: ethyl (4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)carbamate;ZL004
• CAS NO: 1015064-87-5
• Molecular Formula: C16H16N2O5S2
• Molecular Weight: 380.43864
• EINECS: 604-604-1
• Mol File: 1015064-87-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [4-(2,4-Dimethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3]pyrro-6-yl]-carbamic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(2,4-Dimethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3]pyrro-6-yl]-carbamic acid ethyl ester(1015064-87-5)
• EPA Substance Registry System: [4-(2,4-Dimethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3]pyrro-6-yl]-carbamic acid ethyl ester(1015064-87-5)

Safety Data

• Hazardous Substances Data: 1015064-87-5(Hazardous Substances Data)

Usage

General Description

The chemical "[4-(2,4-Dimethoxy-phenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3]pyrro-6-yl]-carbamic acid ethyl ester" is a complex compound with a molecular structure that includes a dithiolo-pyrro-yl group and an ethyl ester of carbamic acid. It contains a 2,4-dimethoxy-phenyl moiety and a 5-oxo-4,5-dihydro group, making it a heterocyclic compound. This chemical is likely to have a range of potential applications, including in the fields of pharmaceuticals, agrochemicals, and materials science, due to its unique molecular structure and properties. Further research and testing would be needed to fully understand and harness the potential of this compound.

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 608132-08-7 4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-hydroxy-1,5-dihydropyrrolidone 
• 944799-69-3 N-[4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide 
• 608132-32-7 4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-trifluoro acetamido-1,5-dihydropyrrolidone 
• 608132-17-8 4-tertbutyl mercapto-5-tertbutyl mercapto methenyl-1-(2,4-dimethoxy-phenyl)-3-amino-1,5-dihydropyrrolidone 

Relevant articles and documents

Discovery of novel N-aryl pyrrothine derivatives as bacterial RNA polymerase inhibitors

Bacterial RNA polymerase (RNAP) is a validated drug target for broad-spectrum antibiotics, and its “switch region” is considered as the promising binding site for novel antibiotics. Based on the core scaffold of dithiolopyrrolone, a series of N-aryl pyrrothine derivatives was designed, synthesized, and evaluated for their antibacterial activity. Compounds generally displayed more active against Gram-positive bacteria, but less against Gram-negative bacteria. Among them, compound 6e exhibited moderate antibacterial activity against clinical isolates of rifampin-resistant Staphylococcus aureus with minimum inhibition concentration value of 1–2?μg/ml and inhibited Escherichia coli RNAP with IC50 value of 12.0?±?0.9?μM. In addition, compound 6e showed certain degree of cytotoxicity against HepG2 and LO2 cells. Furthermore, molecular docking studies suggested that compound 6e might interact with the switch region of bacterial RNAP in a similar conformation to myxopyronin A. Together, the N-aryl pyrrothine scaffold is a promising lead for discovery of antibacterial drugs acting against bacterial RNAP.

DITHIOLOPYRROLONE COMPOUNDS, THE PREPARATION AND THE USE THEREOF

The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X1, R1, R2, R3, R4 are defined as in the description. The invention also

NOVEL DITHIOLOPYRROLONES AND THEIR THERAPEUTICAL APPLICATIONS

The present invention provides novel dithiolopyrrolone compounds and their salts, which promote production of white blood cells and are useful as prevention and treatments for microbial infections such as HIV infection and blood disorders such as neutropenia and other related diseases. The present invention also provides therapeutic compositions comprising particularly useful types of dithiolopyrrolones, the salts thereof, and methods and use in the manufacture of a medication for treatment of diseases.