1015076-80-8

Basic information

• Product Name: (1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid
• Synonyms: (1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid
• CAS NO: 1015076-80-8
• Molecular Weight: 477.462
• Mol File: 1015076-80-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid(1015076-80-8)
• EPA Substance Registry System: (1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid(1015076-80-8)

Safety Data

• Hazardous Substances Data: 1015076-80-8(Hazardous Substances Data)

Upstream product

• 1015076-82-0 (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid 
• 917-54-4 methyllithium 
• 1021952-71-5 (S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol 
• 162515-68-6 1-(sulfanylmethyl)cyclopropaneacetic acid 

Downstream Products

• 158966-92-8 montelukast 

Relevant articles and documents

PROCESS FOR OBTAINING MONTELUKAST

The present invention refers to a process for the synthesis of (1-{1-(R)-(E)-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid or its salts, comprising the reaction between 7-Chloro-2-vinyl-quinoline and a compound of formula (I) wherein X is a halogen atom or a group of formula —OSO2R, wherein R is selected from the group consisting of CF3, tolyl, methyl and F; in the presence of a palladium based catalyst. The invention is also directed to intermediates compounds of the process.