101515-80-4Relevant articles and documents
New Efficient Synthesis of 2-Substituted 5,6,7,8-Tetrahydro-benzo-thieno[2, 3-d]pyrimidin-4(3H)-ones
Ding, Ming-Wu,Yang, Shang-Jun,Zhu, Jing
, p. 75 - 79 (2007/10/03)
The carbodiimides 4, obtained from aza-Wittig reactions of iminophosphorane 3 with aromatic isocyanates, reacted with secondary amines to give 2-dialkylamino-5,6,7,8-tetrahydro-benzothieno[2,3-d]pyrimidin-4(3H)-ones 6 in presence of catalytic EtO-Na+. Reactions of 4 with phenols or ROH in presence of catalytic K2CO3 or RO -Na+ gave 2-aryl(alkyl)oxy-5,6,7,8-tetrahydro- benzothieno[2,3-d]pyrimidin-4(3H)-ones 6 in satisfactory yields. The effects of the nucleophiles on cyclization have been investigated.
Synthesis and biological activities of some 2-(N,N-disubstituted) amino-3-phenyl-thienopyrimidin-4-(3H)-ones
Pathak, U S,Singh, S,Padh, J
, p. 618 - 619 (2007/10/02)
Several 2-(N,N-disubstituted)amino-3-phenylthienopyrimidin-4(3H)-ones (2a-j) have been prepared and tested for their analgesic and CNS depressant activities.
ACYLATION AND BROMINATION OF SOME 2-MERCAPTOTHIENOPYRIMIDINONES AND SYNTHESIS OF THEIR 2-AMINO DERIVATIVES
Khripak, S. M.,Yakubets, V. I.,Dobosh, A. A.
, p. 1091 - 1094 (2007/10/02)
The acylation of 2-thio-3-R-4-oxo-3,4-dihydrothieno-pyrimidines by means of benzoyl chloride was studied.Depending on the reaction conditions, it may take place with formation of S-substituted and N-substituted derivatives.The bromination of the sodium salts of thienopyrimidines and their S- and N-substituted derivatives is accompanied by the formation of disulfides, which do not react with electrophilic reagents but react with amines to give 2-amino derivatives of thienopyrimidines.
