1015255-69-2Relevant academic research and scientific papers
Synthesis of α-ketoamides by a molecular-sieves-promoted formal oxidative coupling of aliphatic aldehydes with isocyanides
Grassot, Jean-Marie,Masson, Geraldine,Zhu, Jieping
, p. 947 - 950 (2008/09/20)
(Chemical Equation Presented) A twist in the Ugi four-component reaction: The reaction of an aldehyde, an isocyanide, N-methylhydroxylamine, and acetic acid in the presence of 4-A molecular sieves afforded α-ketoamides in moderate to good yields (see scheme). In contrast, 3-A molecular sieves did not promote the desired multicomponent reaction. R1 = alkyl; R2 = alkyl, aryl.
