101536-79-2Relevant academic research and scientific papers
Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D2/D3Receptor Bitopic Ligands
Battiti, Francisco O.,Boateng, Comfort A.,Bonifazi, Alessandro,Cao, Jianjing,Chen, Li,Chitsazi, Rezvan,Lee, Kuo Hao,Newman, Amy Hauck,Ravi, Saiprasad,Shaik, Anver Basha,Shi, Lei
, p. 15313 - 15333 (2021/11/01)
The crystal structure of the dopamine D3 receptor (D3R) in complex with eticlopride inspired the design of bitopic ligands that explored (1) N-alkylation of the eticlopride's pyrrolidine ring, (2) shifting of the position of the pyrrolidine nitrogen, (3)
Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides. Relations to other side chain congeners
Hogberg,Strom,De Paulis,Stensland,Csoregh,Lundin,Hall,Ogren
, p. 948 - 955 (2007/10/02)
A number of substituted N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides and -salicylamides have been prepared and investigated as dopamine D-2 receptor antagonists in vitro and in vivo. The affinity was found to be confined to the R enantiomer, in contrast
Synthesis, crystal structure and antidopaminergic properties of eticlopride (FLB 131)
De Paulis,Hall,Ogren,et al.
, p. 273 - 276 (2007/10/02)
The synthesis of the title compounds was achieved by chlorination of 3-ethyl-6-methoxysalicylic acid followed by coupling of the corresponding salicylic acid chloride with S(-)-2-aminomethyl-1-ethylpyrrolidine and S(+)-2-aminomethyl-1-triphenylmethylpyrro
