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101540-26-5

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101540-26-5 Usage

General Description

Arotinolol hydrochloride is a beta-adrenergic blocker and antiarrhythmic medication that is used to treat high blood pressure, angina, and certain types of irregular heartbeats. It works by blocking the action of adrenaline on the heart and blood vessels, which helps to lower blood pressure and reduce the strain on the heart. Arotinolol hydrochloride also has antiarrhythmic properties, which means it can help to regulate the heart's rhythm. It is typically taken orally in the form of tablets and is available by prescription only. Common side effects may include dizziness, fatigue, and nausea, and it should not be used in certain patients with underlying heart conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 101540-26-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,5,4 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 101540-26:
(8*1)+(7*0)+(6*1)+(5*5)+(4*4)+(3*0)+(2*2)+(1*6)=65
65 % 10 = 5
So 101540-26-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H21N3O2S3/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20)

101540-26-5Downstream Products

101540-26-5Relevant articles and documents

Preparation method of arotinolol hydrochloride

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, (2021/02/10)

The invention provides a preparation method of arotinolol hydrochloride, which comprises the following steps of: reacting a compound shown as a structural formula VIII with absolute methanol in the presence of concentrated sulfuric acid to obtain a compou

Preparation process for arotinolol hydrochloride with high purity

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Paragraph 0034; 0035; 0042; 0043; 0050; 0051, (2018/03/26)

The invention discloses a preparation process for arotinolol hydrochloride with high purity. The preparation process comprises the following steps: pouring an acid-binding agent into an alcohol-watercompounded solvent, adding a compound namely 5-(2-sulfhydryl-4-thiazole)-2-thiophenecarboxamide, then adding epichlorohydrin, carrying out a reaction at a room temperature, and carrying out filteringand drying so as to obtain an intermediate III; pouring tert-butylamine into anhydrous ethanol, adding the intermediate III, carrying out a micro-reflux reaction, carrying out concentration, adding purified water, carrying out dissolving under heating, carrying out cooling, adjusting the pH value of an obtained solution to be acidic, carrying out washing with an organic solvent, adding ethanol into an aqueous layer, carrying out dissolving under heating, and carrying out cooling crystallization, and carrying out filtering so as to obtain a crude product; and pouring the crude product into an alcohol-water compounded solvent, carrying out dissolving under heating, and carrying out cooling crystallization, filtering and drying so as to obtain the arotinolol hydrochloride with high purity. The preparation process provided by the invention can effectively remove impurities from arotinolol hydrochloride, can reach a purity of 99.95% or above, and has simple operation and high yield.

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