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101540-79-8

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101540-79-8 Usage

Chemical Properties

Yellow Liquid

Uses

A metabolite of Nicotine

Check Digit Verification of cas no

The CAS Registry Mumber 101540-79-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,5,4 and 0 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 101540-79:
(8*1)+(7*0)+(6*1)+(5*5)+(4*4)+(3*0)+(2*7)+(1*9)=78
78 % 10 = 8
So 101540-79-8 is a valid CAS Registry Number.

101540-79-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-methyl-2-(1-methylpyrrolidin-2-yl)pyridine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101540-79-8 SDS

101540-79-8Relevant articles and documents

Pyrrolidine-modified and 6-substituted analogs of nicotine: a structure-affinity investigation

Dukat, M.,Fiedler, W.,Dumas, D.,Damaj, I.,Martin, B. R.,et al.

, p. 875 - 888 (2007/10/03)

Because the structural requirements for the binding of nicotine to central nicotine receptors remain largely uninvestigated, we undertook a systematic investigation of pyrrolidine ring-opened analogs.This led to a subsequent investigation of related conformationally restricted derivatives of these analogs.The results are reported relative to the binding of several well-known and widely used nicotine receptor ligands.Although none of the ring-opened analogs binds with higher affinity than (-)-nicotine (Ki = 2.3 nM), 3-(N-methyl-N-ethylaminomethyl)pyridine (12a; Ki = 28 nM) binds with significant affinity.A conformationally restricted analog of 12a, N-methyl naphthyridine 30b (Ki = 18 nM), binds with similar affinity. 6-Substitution of 12a and racemic nicotine seems to be tolerated when the substituent is halogen or methyl.In functional studies (hypolocomotion and antinociception in mice; stimulus generalization in nicotine-trained rats) 30b retains nicotine-like properties.Several of the 6-substituted compounds were 2 to 20 times more potent than (+/-)nicotine.Although the intact pyrrolidine ring of nicotine appears important for optimal affinity, its presence is not an absolute requirement for activity, and 6-position substitution of the pyridine nucleus can influence both binding and functional activity. - Keywords: nicotine; nicotine receptor; drug discrimination; antinociception.

THE RADICAL AND ORGANOMETALLIC METHYLATION OF NICOTINE AND NICOTINE N-OXIDE

Secor, Henry V.,Chavdarian, Charles G.,Seeman, Jeffrey I.

, p. 3151 - 3154 (2007/10/02)

2-Methylnicotine is a major product in the reaction nicotine with methyllithium and methyl radical, in addition to the previously reported 4- and 6-methylnicotines.The reaction of nicotine N-oxide with methylmagnesium bromide furnishes both 2- and 6-methylnicotine.

The methylation of nicotine with methyl-lithium.

Haglid

, p. 329 - 334 (2007/10/04)

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