1015460-62-4

Basic information

• Product Name: 9-Bromo-5H-pyrido[4,3-b]indole
• Synonyms: 9-Bromo-5H-pyrido[4,3-b]indole;9-bromo-5H-indeno[1,2-c]pyridine
• CAS NO: 1015460-62-4
• Molecular Formula: C11H7BrN2
• Molecular Weight: 247.09068
• Mol File: 1015460-62-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 443.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.699±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.04±0.40(Predicted)
• CAS DataBase Reference: 9-Bromo-5H-pyrido[4,3-b]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Bromo-5H-pyrido[4,3-b]indole(1015460-62-4)
• EPA Substance Registry System: 9-Bromo-5H-pyrido[4,3-b]indole(1015460-62-4)

Safety Data

• Hazardous Substances Data: 1015460-62-4(Hazardous Substances Data)

Upstream product

• 27246-81-7 3-bromophenylhydrazine hydrochloride 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 244205-40-1 (2-bromophenyl)boronic acid 
• 88511-27-7 3-iodopyridin-4-amine 
• 62829-47-4 1-acetyl-3-bromopiperidin-4-one 

Relevant articles and documents

PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies

The first candidate PI-2014 was tested in healthy controls and subjects with Alzheimer's disease (AD). As PI-2014 displayed off-target binding to monoamine oxidase A (MAO-A), a new lead with improved binding to Tau and decreased MAO-A binding was required. For compound optimization, Tau binding assays based on both human AD brain homogenate and Tau-paired helical filaments were employed. Furthermore, two MAO-A screening assays based on (1) human-recombinant MAO-A and (2) displacement of 2-fluoro-ethyl-harmine from mouse brain homogenate were employed. Removing the N-methyl group from the tricyclic core resulted in compounds displaying improved Tau binding. For the final round of optimization, the cyclic amine substituents were replaced by pyridine derivatives. PI-2620 (2-(2-fluoropyridin-4-yl)-9H-pyrrolo[2,3-b:4,5-c′]dipyridine) emerged as a best candidate displaying high Tau binding, low MAO-A binding, high brain uptake, and fast and complete brain washout. Furthermore, PI-2620 showed Tau binding on brain sections from corticobasal degeneration, progressive supranuclear palsy, and Pick's disease.

Organic light-emitting device

The present invention relates to an organic light emitting device having excellent electrical properties and thermal stability, which comprises: a first electrode; a second electrode; and an organic layer disposed between the first and second electrodes,

Microwave-enhanced Fischer reaction: An efficient one-pot synthesis of γ-carbolines

γ-Carbolines were obtained in a simple one-pot Fischer reaction starting from N-acetyl-3-bromo-4-piperidone hydrobromide and substituted arylhydrazine hydrochlorides in acidic media under microwave irradiation or by a thermal process. The optimization procedures are reported in detail, and the results from microwave processes are compared with conventional ones. Georg Thieme Verlag Stuttgart.