1015484-07-7Relevant articles and documents
2,6-Diaryl-4-phenacylaminopyrimidines as potent and selective adenosine A2A antagonists with reduced hERG liability
Moorjani, Manisha,Zhang, Xiaohu,Chen, Yongsheng,Lin, Emily,Rueter, Jaimie K.,Gross, Raymond S.,Lanier, Marion C.,Tellew, John E.,Williams, John P.,Lechner, Sandra M.,Malany, Siobhan,Santos, Mark,Ekhlassi, Paddi,Castro-Palomino, Julio C.,Crespo, Maria I.,Prat, Maria,Gual, Silvia,Diaz, Jose-Luis,Saunders, John,Slee, Deborah H.
, p. 1269 - 1273 (2008/09/18)
In this report, the design and synthesis of a series of pyrimidine based adenosine A2A antagonists are described. The strategy and outcome of expanding SAR exploration to attenuate hERG and improve selectivity over A1 are discussed.
