101573-69-7Relevant academic research and scientific papers
Copper-catalyzed reductive coupling of tosylhydrazones with amines: A convenient route to α-branched amines
Hamze, Abdallah,Treguier, Bret,Brion, Jean-Daniel,Alami, Mouad
supporting information; experimental part, p. 6200 - 6204 (2011/10/08)
A general procedure for the reductive coupling of N-tosylhydrazones with amines in the presence of Cu(acac)2 and Cs2CO3 has been developed. The protocol is very effective and chemoselective with various primary and secondary aliphatic amines, aminoalcohols as well as azole derivatives to give α-branched amines in good yields.
Sequential addition reactions of two molecules of Grignard reagents to thioformamides
Murai, Toshiaki,Ui, Kazuki,Narengerile
scheme or table, p. 5703 - 5706 (2009/12/06)
(Chemical Equation Presented) Sequential addition reactions of two molecules of Grignard reagents to thioformamides were found to yield tertiary amines in an efficient manner. The addition of two different Grignard reagents can be accomplished by using one equivalent of arylmagnesium reagent in the first step. In the second step, a variety of reagents such as alkyl, alkenyl, aryl, and alkynyl reagents were used to afford the corresponding amines in good to high yields.
