1015759-12-2

Basic information

• Product Name: 2-methyl-6-(p-tolyl)pyridine N-oxide
• Synonyms: 2-methyl-6-(p-tolyl)pyridine N-oxide
• CAS NO: 1015759-12-2
• Molecular Weight: 199.252
• Mol File: 1015759-12-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-methyl-6-(p-tolyl)pyridine N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-6-(p-tolyl)pyridine N-oxide(1015759-12-2)
• EPA Substance Registry System: 2-methyl-6-(p-tolyl)pyridine N-oxide(1015759-12-2)

Safety Data

• Hazardous Substances Data: 1015759-12-2(Hazardous Substances Data)

Upstream product

• 101893-57-6 2-methyl-6-(p-tolyl)pyridine 
• 1125-34-4 6-methyl-1-oxy-pyridine-2-carboxylic acid 
• 106-38-7 para-bromotoluene 
• 624-31-7 4-tolyl iodide 
• 931-19-1 2-methylpyridine N-oxide 

Downstream Products

• 1015758-88-9 2-(2-methylbenzyl)-6-p-tolylpyridine 1-oxide 

Relevant articles and documents

Recent developments in the chemistry of heteroaromatic N -oxides

Selected developments in the chemistry of heteroaromatic N-oxides since 2001 are presented in this review. The use of these N-oxides, both in late-transition-metal-catalyzed oxidations of carbon-carbon triple bonds and in regioselective C-H functionalizations of the heteroarene, are contemporary topics of interest and the focus of the discussion. 1 Introduction 2 Synthesis of Heteroaromatic N-Oxides 2.1 Direct Oxidation of Hindered Heteroarenes 2.2 Through Construction of Heteroaromatic Rings 3 Heteroaromatic N-Oxides as Oxidants 3.1 Alkyne Oxidation 3.2 Allene Oxidation 3.3 Carbene Oxidation 4 Heteroaromatic N-Oxides as Substrates 4.1 Deoxygenative ortho-C-H Functionalization with Prior Activation 4.2 Deoxygenative ortho-C-H Functionalization with Nonstabilized Carbanions 4.3 Nondeoxygenative C-H Functionalization 4.3.1 ortho-C-H Functionalization 4.3.2 N-Oxide Directed ortho-Alkyl C-H Functionalization 4.3.3 N-Oxide Directed Remote C-H Functionalization 4.4 1,3-Dipolar Cycloaddition 5 Conclusion and Outlook.

Palladium-Catalyzed Direct Arylation of Azine and Azole N-Oxides: Reaction Development, Scope and Applications in Synthesis

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Site-selective sp2 and benzylic sp3 palladium-catalyzed direct arylation

Palladium-catalyzed site selective arylation reactions of both sp2 and benzylic sp3 sites on azine and diazine N-oxide substrates are described that occur in good to excellent yield and with complete selectivity for reaction at the desired position. These studies have uncovered the need to properly control the metal to ligand ratio in sp2 arylation and necessitated a complete reinvestigation of all reaction parameters for sp3 arylation. From these studies, the choice of base emerged as a pivotal component for site selectivity, pointing to its intimate involvement in the mechanism of direct arylation. These site selective reactions have been validated in both divergent and sequential derivatizations of heterocyclic compounds represent an attractive alternative to other routes to this class of molecule. Copyright