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Trenbolone Acetate CAS10161-34-9
Cas No: 10161-34-9
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10161-34-9 Usage

Description

Trenbolone acetate (brand name: Revalor) is a 19-nortestosterone derivative and a synthetic, injected anabolic-androgenic steroid that is used in veterinary medicine. It is a highly efficient anabolic steroid that can greatly enhance the performance of athletes. Trenbolone acetate has several physiological effects. First, it can greatly promote insulin-like growth factor-1 (IGF-1). IGF-1 is a powerful and natural anabolic hormone that of great importance for muscle tissue development. Secondly, it can greatly increase the red blood cell count, further increasing blood oxygen and enhancing muscular endurance. Moreover, it can inhibit the glucocorticoid hormone, a hormone that destroy muscle tissue and promote fat. Finally, it can improve nutrient uptake and consumption efficiency.

Chemical Properties

Pale Yellow Solid

Originator

Parabolan,Negma,France,1980

Uses

A steroid used to increase the muscle growth of livestock.

Uses

anti-cataract agent

Manufacturing Process

Stage A: Preparation of 17β-Benzoyloxy-Estra-4,9,11-Trien-3-one - 0.400 g of 17β-benzoyloxy-4,5-seco-estra-9,11-diene-3,5-dione is dissolved in 4 cc of toluene under an inert atmosphere. The solution is cooled to 3°C, then 0.48 cc is added of the solution of sodium tert-amylate in anhydrous toluene, diluted by the addition of a further 4.8 cc of anhydrous toluene. This reaction mixture is kept between 0°C and +5°C for six hours, with agitation and under an inert atmosphere, then 5 cc of a 0.2 N solution of acetic acid in toluene are added. The mixture is extracted with toluene, and the extracts are washed with water and evaporated to dryness. The residue is taken up in ethyl acetate, and then the solution is evaporated to dryness in vacuo, yielding a resin which is dissolved in methylene chloride, and the solution passed through a column of 40 g of magnesium silicate. Elution is carried out first with methylene chloride, then with methylene chloride containing 0.5% of acetone, and 0.361 g is thus recovered of a crude product, which is dissolved in 1.5 cc of isopropyl ether; then hot methanol is added and the mixture left at 0°C for one night. 0.324 g of the desired 17β-benzoyloxy-estra-4,9,11-trien-3-one are thus finally obtained, being a yield of 85%, melting point is 154°C. Stage B: Preparation of 17β-Hydroxy-Estra-4,9,11-Trien-3-one - 3 g of 17β- benzoyloxy-estra-4,9,11-trien-3-one, obtained as described in Stage A are dissolved in 15 cc of methanol. 0.03 g of hydroquinone is added, and the mixture is taken to reflux while bubbling in nitrogen. Then 1.2 cc of 11% methanolic caustic potash is added and reflux is maintained for three hours, after which the reaction product is acidified with 0.36 cc of acetic acid. The methyl benzoate thus formed is eliminated by steam distillation, and 2.140 g of crude product are obtained, which are dissolved in 20 cc of methylene chloride. This solution is passed through 10 parts of magnesium silicate, elution being performed with 250 cc of methylene chloride containing 5% of acetone. After evaporation of the solvent 2.050 g of product is recovered, which is recrystallized from isopropyl ether. In this way 1.930 g of the desired 17β-hydroxy-estra-4,9,11-trien-3-one is obtained being a yield of 89%, melting point is 186°C. It is converted to the acetate by acetic anhydride.

Brand name

[Trenbolone is INN and BAN.

Therapeutic Function

Anabolic steroid

References

https://en.wikipedia.org/wiki/Trenbolone_acetate Henricks, D. M., et al. "Serum concentrations of trenbolone-17 beta and estradiol-17 beta and performance of heifers treated with trenbolone acetate, melengestrol acetate, or estradiol-17 beta." Journal of Animal Science 75.10(1997):2627-33. https://www.steroid.com/trenbolone-acetate.php
InChI:InChI=1/C20H24O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h9-11,17-19H,3-8H2,1-2H3

10161-34-9 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1673828)  Trenboloneacetate  United States Pharmacopeia (USP) Reference Standard 10161-34-9 1673828-200MG 4,926.87CNY Detail

10161-34-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Trenbolone Acetate

1.2 Other means of identification

Product number -
Other names Revalor-H

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Veterinary Drug: GROWTH_PROMOTER
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10161-34-9 SDS

10161-34-9Related news

The effect of combination treatment with Trenbolone acetate (cas 10161-34-9) and estradiol-17β on skeletal muscle expression and plasma concentrations of oxytocin in sheep07/23/2019

Implantation of trenbolone acetate (TBA) in conjunction with estradiol-17β (E2) increases growth, feed conversion efficiency, and carcass leanness in cattle. Our previous study in Brahman steers suggested that the neuropeptide hormone oxytocin (OXT) may be involved in increasing muscle growth a...detailed

The transcriptome of muscle and liver is responding differently to a combined Trenbolone acetate (cas 10161-34-9) and estradiol implant in cattle07/22/2019

We investigated the transcriptomic signature of some anabolic steroids in cattle. Our main objective was to evaluate the effect of a combined trenbolone acetate (TBA, 200 mg) and estradiol-17β (E2, 40 mg) implant (Revalor-XS®, REV) on the transcriptome of muscle (target tissue for anabolic ster...detailed

Reproductive toxicity of Trenbolone acetate (cas 10161-34-9) in embryonically exposed Japanese quail07/20/2019

This study was conducted to assess the effects of a one time embryonic exposure to trenbolone acetate on reproductive development and function in Japanese quail (Coturnix japonica). Embryos were exposed to either 0.05, 0.5, 5, or 50 μg trenbolone or a sesame oil vehicle control at embryonic day...detailed

Analysis of Trenbolone acetate (cas 10161-34-9) metabolites and melengestrol in environmental matrices using gas chromatography–tandem mass spectrometry07/19/2019

Studies demonstrate that exposure to steroid hormones in receiving waters can adversely impact reproduction of aquatic organisms. In particular, exogenous steroid hormones widely used as growth promoters in animal agriculture are of high concern, yet no gas chromatography–tandem mass spectromet...detailed

The Trenbolone acetate (cas 10161-34-9) affects the immune system in rainbow trout, Oncorhynchus mykiss07/17/2019

In aquatic systems, the presence of endocrine-disrupting chemicals (EDC) can disrupt the reproductive function but also the immune system of wildlife. Some studies have investigated the effects of androgens on the fish immune parameters but the mechanisms by which the xenoandrogens alter the imm...detailed

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