10161-34-9

Basic information

• Product Name: Trenbolone acetate
• Synonyms: Revalor-H Trenbolone acetate;Trenbolone Acetate 98%Min (Revalor-H);Trenbolone Acetate API;Trenbolone Acetate(Revalor-H);Trenbolone acetate solution;Trenbolone Acetate (Finaplix H/Revalor-H);Trenbolone Acetate /Finaplix;17-(acetyloxy)-(17-beta)-estra-11-trien-3-one
• CAS NO: 10161-34-9
• Molecular Formula: C₂₀H₂₄O₃
• Molecular Weight: 312.4
• EINECS: 233-432-5
• Product Categories: trenbolone series;Hormone Drugs;Inhibitors;Hormone;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;Finished Steroid and Hormone
• Mol File: 10161-34-9.mol

Chemical Properties

• Melting Point: 90-92°C
• Boiling Point: 392.32°C (rough estimate)
• Flash Point: 214.7 °C
• Appearance: yellow or yellow-white crystalline powder
• Density: 1.1464 (rough estimate)
• Vapor Pressure: 1.26E-09mmHg at 25°C
• Refractive Index: 1.4618 (estimate)
• Storage Temp.: 0-6°C
• CAS DataBase Reference: Trenbolone acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Trenbolone acetate(10161-34-9)
• EPA Substance Registry System: Trenbolone acetate(10161-34-9)

Safety Data

• Hazard Codes: T
• Statements: 60
• Safety Statements: 22-36/37/39-45
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: KG7753500
• Hazardous Substances Data: 10161-34-9(Hazardous Substances Data)

Usage

Uses

Used in Livestock Industry:
Trenbolone acetate is used as a muscle growth enhancer for livestock, improving their overall performance and growth.
Used in Veterinary Medicine:
Trenbolone acetate is used as an anti-cataract agent in veterinary medicine, helping to prevent and treat cataracts in animals.
Used in Athletic Performance:
Trenbolone acetate is used as a performance-enhancing drug for athletes, promoting muscle growth, increasing red blood cell count, and improving endurance and nutrient uptake.

Manufacturing Process

Stage A: Preparation of 17β-Benzoyloxy-Estra-4,9,11-Trien-3-one - 0.400 g of 17β-benzoyloxy-4,5-seco-estra-9,11-diene-3,5-dione is dissolved in 4 cc of toluene under an inert atmosphere. The solution is cooled to 3°C, then 0.48 cc is added of the solution of sodium tert-amylate in anhydrous toluene, diluted by the addition of a further 4.8 cc of anhydrous toluene. This reaction mixture is kept between 0°C and +5°C for six hours, with agitation and under an inert atmosphere, then 5 cc of a 0.2 N solution of acetic acid in toluene are added. The mixture is extracted with toluene, and the extracts are washed with water and evaporated to dryness. The residue is taken up in ethyl acetate, and then the solution is evaporated to dryness in vacuo, yielding a resin which is dissolved in methylene chloride, and the solution passed through a column of 40 g of magnesium silicate. Elution is carried out first with methylene chloride, then with methylene chloride containing 0.5% of acetone, and 0.361 g is thus recovered of a crude product, which is dissolved in 1.5 cc of isopropyl ether; then hot methanol is added and the mixture left at 0°C for one night. 0.324 g of the desired 17β-benzoyloxy-estra-4,9,11-trien-3-one are thus finally obtained, being a yield of 85%, melting point is 154°C. Stage B: Preparation of 17β-Hydroxy-Estra-4,9,11-Trien-3-one - 3 g of 17β- benzoyloxy-estra-4,9,11-trien-3-one, obtained as described in Stage A are dissolved in 15 cc of methanol. 0.03 g of hydroquinone is added, and the mixture is taken to reflux while bubbling in nitrogen. Then 1.2 cc of 11% methanolic caustic potash is added and reflux is maintained for three hours, after which the reaction product is acidified with 0.36 cc of acetic acid. The methyl benzoate thus formed is eliminated by steam distillation, and 2.140 g of crude product are obtained, which are dissolved in 20 cc of methylene chloride. This solution is passed through 10 parts of magnesium silicate, elution being performed with 250 cc of methylene chloride containing 5% of acetone. After evaporation of the solvent 2.050 g of product is recovered, which is recrystallized from isopropyl ether. In this way 1.930 g of the desired 17β-hydroxy-estra-4,9,11-trien-3-one is obtained being a yield of 89%, melting point is 186°C. It is converted to the acetate by acetic anhydride.

References

https://en.wikipedia.org/wiki/Trenbolone_acetate Henricks, D. M., et al. "Serum concentrations of trenbolone-17 beta and estradiol-17 beta and performance of heifers treated with trenbolone acetate, melengestrol acetate, or estradiol-17 beta." Journal of Animal Science 75.10(1997):2627-33. https://www.steroid.com/trenbolone-acetate.php

InChI:InChI=1/C20H24O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h9-11,17-19H,3-8H2,1-2H3

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