1016167-99-9

Usage

Uses

Used in Pharmaceutical Synthesis:
(S)-3-(Boc-aMinoMethyl)-piperidine is utilized as a key intermediate in the synthesis of pharmaceuticals, leveraging its Boc-protected amino group for the creation of complex molecular structures. (S)-3-(Boc-aMinoMethyl)-piperidine's stability and reactivity facilitate the development of new drugs with specific therapeutic properties.
Used in Organic Chemistry:
In the field of organic chemistry, (S)-3-(Boc-aMinoMethyl)-piperidine serves as a versatile building block for the assembly of a wide range of organic compounds. Its Boc-protected amino group allows for selective reactions and deprotection, enhancing the synthesis process and enabling the creation of diverse chemical entities.
Used in Medicinal Chemistry:
(S)-3-(Boc-aMinoMethyl)-piperidine is employed as a structural component in medicinal chemistry for the design and development of novel therapeutic agents. Its unique properties contribute to the optimization of drug candidates, potentially leading to improved pharmacokinetics, pharmacodynamics, and safety profiles.
Used in Chemical Research:
In research settings, (S)-3-(Boc-aMinoMethyl)-piperidine is applied as a model compound to study various chemical reactions and mechanisms. Its predictable reactivity and the ability to selectively deprotect the Boc group make it an ideal candidate for probing the limits and possibilities of synthetic organic chemistry.

Upstream product

• 290363-59-6 C₁₃H₂₀N₂ 
• 1026661-43-7 (S)-piperidine-3-carboxylic acid amide hydrochloride 
• 142643-29-6 tert-butyl (piperidin-3-ylmethyl)carbamate 

Downstream Products

• 1391739-80-2 tert-butyl ((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615250-07-1 tert-butyl ((R)-1-((R)-3-(4-methylbenzyl)-2-oxothiazolidine-4-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-86-9 tert-butyl ((R)-1-((S)-1-(2-bromobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-80-3 tert-butyl ((R)-1-((S)-1-benzyl-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-79-0 tert-butyl ((S)-1-((S)-1-benzyl-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615250-13-9 tert-butyl ((S)-1-((R)-4-(4-methylbenzyl)-5-oxothiomorpholine-3-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615250-12-8 tert-butyl ((R)-1-(((S)-1-(4-methylbenzyl)-6-oxopiperidin-2-yl)methyl)piperidin-3-yl)methylcarbamate 
• 1615250-09-3 tert-butyl ((R)-1-((R)-3-(4-methylbenzoyl)thiazolidine-4-carbonyl) piperidin-3-yl)methylcarbamate 
• 1615250-08-2 tert-butyl ((R)-1-((R)-3-(4-methylbenzyl)thiazolidine-4-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-96-1 tert-butyl ((R)-1-((S)-1-(4-cyanobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-92-7 tert-butyl ((R)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-88-1 tert-butyl ((R)-1-((S)-1-(4-bromobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-84-7 tert-butyl ((R)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate 
• 1615250-06-0 tert-butyl ((R)-1-((S)-3-(4-methylbenzyl)-2-oxooxazolidine-4-carbonyl)piperidin-3-yl)methylcarbamate 

Relevant academic research and scientific papers

Preparation and structure confirmation new methods of (S)-3-Boc-aminomethylpiperidine

The invention discloses preparation and structure confirmation of (S)-3-Boc-aminomethylpiperidine. A compound 5 is obtained by benzylation of a compound 1, reduction of a carbonyl group, protection ofan amino group, and catalytic hydrogenation; then the compound 5 is subjected to derivation to obtain a crystal; the crystal is subjected to diffraction test and analyzed to obtain that the compound5 is the (S)-3-Boc-aminomethylpiperidine, and the optical rotation is -8.98, which further proves that the method for preparing the compound 5 is feasible. According to the preparation method, the cheap and easily available chiral raw material compound 1 is used without using a resolving agent, and the advantages in yield and cost are realized; the product is tested by derivatization and diffraction way to determine the correct configuration, and the preparation and confirmation methods form a system, thereby facilitating industrial production and realizing a broad application prospect.

CHIRAL 1-(4-METHYLPHENYLMETHYL)-5-OXO-{N-[(3-T-BUTOXYCARBONYL- AMINOMETHYL)]-PIPERIDIN-1-YL}-PYRROLIDINE-2-CARBOXAMIDES AS INHIBITORS OF COLLAGEN INDUCED PLATELET ACTIVATION AND ADHESION

Chiral l-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]- piperidin-l-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion The present invention provides chiral (2S)-l-(4-methylphenylmethyl)-5-oxo-(3S)-{N-[(3-t- butoxycarbonyl aminomethyl)]-piperidin-l-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4- methylphenylmethyl)-5-oxo-(3R)-{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-l-yl}- pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p- methylphenylmethyl)lpyroglutamate in good chiral purity.