1016167-99-9Relevant articles and documents
Preparation and structure confirmation new methods of (S)-3-Boc-aminomethylpiperidine
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Paragraph 0025; 0029; 0037; 0038; 0058, (2018/09/11)
The invention discloses preparation and structure confirmation of (S)-3-Boc-aminomethylpiperidine. A compound 5 is obtained by benzylation of a compound 1, reduction of a carbonyl group, protection ofan amino group, and catalytic hydrogenation; then the compound 5 is subjected to derivation to obtain a crystal; the crystal is subjected to diffraction test and analyzed to obtain that the compound5 is the (S)-3-Boc-aminomethylpiperidine, and the optical rotation is -8.98, which further proves that the method for preparing the compound 5 is feasible. According to the preparation method, the cheap and easily available chiral raw material compound 1 is used without using a resolving agent, and the advantages in yield and cost are realized; the product is tested by derivatization and diffraction way to determine the correct configuration, and the preparation and confirmation methods form a system, thereby facilitating industrial production and realizing a broad application prospect.