1016169-38-2Relevant academic research and scientific papers
Synthesis of 1,3,4-Trisubstituted and 1,3,4,5-Tetrasubstituted Pyrazoles
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Page/Page column 10; 15, (2009/04/24)
This invention concerns the synthesis of highly substituted pyrazoles, which are structural components of pharmacological compounds, through reaction of hydrazones with nitroolefins.
Base-mediated reaction of hydrazones and nitroolefins with a reversed regioselectivity: A novel synthesis of 1,3,4-Trisubstituted pyrazoles
Deng, Xiaohu,Mani, Neelakandha S.
supporting information; body text, p. 1307 - 1310 (2009/04/06)
A regioselective synthesis of 1,3,4-tri- or 1,3,4,5-tetrasubstituted pyrazoles by the reaction of hydrazones with nitroolefins is described. Mediated with strong bases such as t-Bu OK, the reaction exhibits a reversed, exclusive 1,3,4-regioselectivity. Su
