1016261-63-4

Upstream product

• 37614-59-8 4-(4-methoxyphenyl)prop-2-yn-1-ol 
• 1016-19-9 3,4,5-trimethoxyphenylisocyanate 

Downstream Products

• 1016261-70-3 (Z)-4-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)oxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis of 4-benzyliden-2-oxazolidinone derivatives via gold-catalyzed intramolecular hydroamination

AuCl-catalyzed intramolecular hydroamination of N-aryl-O-propargyl carbamates (3) efficiently affords (Z)-N-aryl-4-benzyliden-2-oxazolidinones (4) via a 5-exo dig cyclization. The reaction proceeds in acetonitrile at 60 °C and requires tBuOK or KOH as a base co-catalyst. It tolerates the presence of multiple substituted aryl units with electron donating methoxy groups. The method opens a convenient, flexible and operationally simple access to a new class of twisted molecules with potentially interesting biological properties.