101640-02-2

Upstream product

• 77333-53-0 (E)-4-(4-Chloro-3-methoxy-5-methylamino-phenyl)-3-methyl-but-2-enoic acid methyl ester 
• 101640-00-0 {(E)-4-[4-Chloro-3-methoxy-5-(methyl-oct-7-enoyl-amino)-phenyl]-3-methyl-but-2-enyl}-triphenyl-phosphonium; bromide 
• 101640-01-1 Oct-7-enoic acid {2-chloro-3-methoxy-5-[(2E,4E)-2-methyl-7-(tetrahydro-pyran-2-yloxy)-hepta-2,4-dienyl]-phenyl}-methyl-amide 
• 77333-54-1 (E)-4-(4-Chloro-3-methoxy-5-methylamino-phenyl)-3-methyl-but-2-en-1-ol 
• 64095-22-3 1-<4-chloro-3-methoxy-5-(methylamino)phenyl>-2-propanone 
• 101639-95-6 oct-7-enoyl chloride 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Relevant academic research and scientific papers

MODEL STUDIES FOR THE TOTAL SYNTHESIS OF THE MAYTANSINOIDS BASED ON THE INTRAMOLECULAR NITRILE OXIDE-OLEFIN CYCLOADDITION REACTION

The macrocyclization of the olefinic nitrile oxide 30 to the ansa-macrolide skeleton 37, a model for a novel approach to the maytansinoids, is described.

THE INTRAMOLECULAR NITRILE OXIDE-OLEFIN CYCLOADDITION ROUTE TO THE MAYTANSINOIDS

The macrocyclization of the olefinic nitrile oxide 24 to the ansa-macrolide skeleton 26, a model for a novel approach to the maytansinoids, is described.