101649-97-2

Upstream product

• 1072-72-6 Tetrahydrothiopyran-4-one 
• 495-69-2 Hippuric Acid 
• 101649-87-0 (1S,2R,5S)-menthyl N-benzoylglycinate 
• 101649-84-7 (+)-menthyl 2-benzoylamino-2-bromoacetate 
• 101649-95-0 (+)-menthyl (1'S,2R)-2-benzoylamino-2-(4-oxotetrahydrothiopyran-3-yl)acetate 
• 101649-96-1 (S)-4-(2-methoxymethyl)pyrrolidino-5,6-dihydro-2H-thiopyran 
• 15356-60-2 (1S,2R,5S)-(+)-menthol 

Relevant academic research and scientific papers

SYNTHESIS OF DIASTEREO- AND ENANTIOMERICALLY PURE α-AMINO-γ-OXO ACID ESTERS BY REACTION OF ACYLIMINOACETATES WITH ENAMINES DERIVED FROM 6-MEMBERED KETONES

A new efficient diastereo- and enantioselective synthesis of α-amino-γ-oxo acid esters by reaction of acyliminoacetates with enamines is described.By employing the concept of double stereodifferentiation, complete asymmetric induction (de=ee >/= 99.9 percent) for the C-C bond formation is obtained.Desulphurization of a sulphur containing product leads to the corresponding acyclic amino acid derivatives.The virtually complete anti-diastereo- and enantioselectivities are interpreted by a Diels-Alder like transition state.