101654-37-9Relevant academic research and scientific papers
A Convenient Synthesis of High-Purity 1-Chloro-2,6-difluorobenzene
Moore Jr., Robert M.
, p. 921 - 924 (2003)
A convenient preparation of high-purity 1-chloro-2,6-difluorobenzene has been developed. The key to the isolation of the desired isomer, without contamination of the difficult-to-separate isomer 1-chloro-2,3-difluorobenzene, is the use of sulfonyl chloride to direct fluorine substitution to the ortho and para positions of the aryl ring. Although activation with sulfonyl chloride requires additional reaction steps, the process results in good overall yield and requires only low-cost commodity chemicals. The high-purity 1-chloro-2,6-difluorobenzene is useful as an intermediate for active ingredients in agricultural and pharmaceutical applications.
