101663-45-0

Basic information

• Product Name: Benzenemethanamine, N-methyl-N-(3-methylphenyl)-
• CAS NO: 101663-45-0
• Molecular Formula: C15H17N
• Molecular Weight: 211.307
• Mol File: 101663-45-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, N-methyl-N-(3-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, N-methyl-N-(3-methylphenyl)-(101663-45-0)
• EPA Substance Registry System: Benzenemethanamine, N-methyl-N-(3-methylphenyl)-(101663-45-0)

Safety Data

• Hazardous Substances Data: 101663-45-0(Hazardous Substances Data)

Upstream product

• 108-41-8 1-chloro-3-methylbenzene 
• 103-67-3 benzyl-methyl-amine 
• 615-37-2 ortho-methylphenyl iodide 
• 100-46-9 benzylamine 
• 17933-03-8 m-tolylboronic acid 
• 57212-27-8 N-methyl-N-m-tolylbenzamide 

Relevant articles and documents

Well-defined NHC-Pd(II)-Im (NHC=N-heterocyclic carbene; Im=1-methylimidazole) complexes catalyzed amination of aryl chlorides

A new class of well-defined NHC-Pd(II)-Im complexes was synthesized and was found to be an efficient catalyst for the amination reactions of aryl chlorides. Under the optimal reaction conditions, a range of amines can be coupled to give the amination products in good to high yields.

Synthesis of N-heterocyclic carbene-Pd(II)-5-phenyloxazole complexes and initial studies of their catalytic activity toward the Buchwald-Hartwig amination of aryl chlorides

Three new N-heterocyclic carbene (NHC)-Pd(II) complexes using 5-phenyloxazole as the ancillary ligand have been obtained in moderate to good yields by a one-pot reaction of the corresponding imidazolium salts, palladium chloride and 5-phenyloxazole under mild conditions. Initial studies showed that one of the complexes is an efficient catalyst for the Buchwald-Hartwig amination of aryl chlorides with various secondary and primary amines under the varied catalyst loading of 0.01-0.05 mol%, thus it will enrich the chemistry of NHCs and give an alternative catalyst for the coupling of challenging while cost-low aryl chlorides.

Heterogeneous Catalytic Reduction of Tertiary Amides with Hydrosilanes Using Unsupported Nanoporous Gold Catalyst

We have demonstrated that the unsupported nanoporous gold (AuNPore) was a green and highly efficient heterogeneous catalyst for the reduction of amides to amines using hydrosilanes as reductants. A variety of tertiary amides with a broad functional groups were reduced to the corresponding tertiary amines in the presence of 2 mol% of AuNPore and PheMe2SiH or (Me2SiH)2O under mild conditions. AuNPore catalyst was recovered by simple filtration and used for twelve times without any loss of catalytic activity. The AuNPore/hydrosilane system was also successfully applied to the hydrosilative reduction of sulfoxides and N-oxides. (Figure presented.).

Synthesis of N-heterocyclic carbene-Pd(II) complexes and their catalytic activity in the Buchwald-Hartwig amination of aryl chlorides

Novel N-heterocyclic carbene-palladium(II) complexes using 2-picolinic acid as the ancillary ligand have been successfully developed under mild conditions. Their catalytic activity in organic synthesis has been initially tested in the Buchwald-Hartwig amination of secondary and primary amines with aryl chlorides. Various substituents on both substrates can be tolerated, giving the desired coupling products in good to almost quantitative yields. The minimum catalyst loading can be 0.01 mol%, implying their potential application toward industrial processes.