1016640-36-0

Basic information

• Product Name: C₃₄H₄₂N₄O₁₁
• Synonyms: C₃₄H₄₂N₄O₁₁
• CAS NO: 1016640-36-0
• Molecular Weight: 682.728
• Mol File: 1016640-36-0.mol

Chemical Properties

• CAS DataBase Reference: C₃₄H₄₂N₄O₁₁(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₄H₄₂N₄O₁₁(1016640-36-0)
• EPA Substance Registry System: C₃₄H₄₂N₄O₁₁(1016640-36-0)

Safety Data

• Hazardous Substances Data: 1016640-36-0(Hazardous Substances Data)

Upstream product

• 1016640-17-7 C₃₆H₄₆N₄O₁₁ 

Relevant articles and documents

RCM macrocyclization made practical: An efficient synthesis of HCV protease inhibitor BILN 2061

We report here that dramatic improvement of the key RCM reaction in the synthesis of HCV protease inhibitor BILN2061 can be achieved by N-substitution of the diene substrate with an electron-withdrawing group. Mechanistic studies using 1H NMR spectroscopy showed an unprecedented switch of the initiation sites and the correlation between such switch and the results of RCM, from the unmodified to the modified substrates. We also provided theoretical evidence that such modification may also increase the thermodynamic preference of the macro cyclic product over the diene substrate.