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1016670-99-7

N-(3-amino-4-methylphenyl)-3-methylbenzamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1016670-99-7 Structure

  • Basic information

    1. Product Name: N-(3-amino-4-methylphenyl)-3-methylbenzamide
    2. Synonyms: N-(3-amino-4-methylphenyl)-3-methylbenzamide
    3. CAS NO:1016670-99-7
    4. Molecular Formula:
    5. Molecular Weight: 240.305
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1016670-99-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(3-amino-4-methylphenyl)-3-methylbenzamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(3-amino-4-methylphenyl)-3-methylbenzamide(1016670-99-7)
    11. EPA Substance Registry System: N-(3-amino-4-methylphenyl)-3-methylbenzamide(1016670-99-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1016670-99-7(Hazardous Substances Data)

1016670-99-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1016670-99-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,6,6,7 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1016670-99:
(9*1)+(8*0)+(7*1)+(6*6)+(5*6)+(4*7)+(3*0)+(2*9)+(1*9)=137
137 % 10 = 7
So 1016670-99-7 is a valid CAS Registry Number.

1016670-99-7Downstream Products

1016670-99-7Relevant articles and documents

Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia

Liang, Xiaofei,Liu, Xiaochuan,Wang, Beilei,Zou, Fengming,Wang, Aoli,Qi, Shuang,Chen, Cheng,Zhao, Zheng,Wang, Wenchao,Qi, Ziping,Lv, Fengchao,Hu, Zhenquan,Wang, Li,Zhang, Shanchun,Liu, Qingsong,Liu, Jing

, p. 1984 - 2004 (2016)

Starting from a dihydropyrimidopyrimidine core scaffold based compound 27 (GNF-7), we discovered a highly potent (ABL1: IC50 of 70 nM) and selective (S score (1) = 0.02) BCR-ABL inhibitor 18a (CHMFL-ABL-053). Compound 18a did not exhibit apparent inhibitory activity against c-KIT kinase, which is the common target of currently clinically used BCR-ABL inhibitors. Through significant suppression of the BCR-ABL autophosphorylation (EC50 about 100 nM) and downstream mediators such as STAT5, Crkl, and ERK's phosphorylation, 18a inhibited the proliferation of CML cell lines K562 (GI50 = 14 nM), KU812 (GI50 = 25 nM), and MEG-01 (GI50 = 16 nM). A pharmacokinetic study revealed that 18a had over 4 h of half-life and 24% bioavailability in rats. A 50 mg/kg/day dosage treatment could almost completely suppress tumor progression in the K562 cells inoculated xenograft mouse model. As a potential useful drug candidate for CML, 18a is under extensive preclinical safety evaluation now.

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