1016680-08-2

Basic information

• Product Name: 1-(2,4-difluorophenyl)piperidin-4-one
• Synonyms: 1-(2,4-difluorophenyl)piperidin-4-one
• CAS NO: 1016680-08-2
• Molecular Formula: C₁₁H₁₁F₂NO
• Molecular Weight: 211.2079464
• Mol File: 1016680-08-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 318.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.267±0.06 g/cm3(Predicted)
• PKA: 5.07±0.40(Predicted)
• CAS DataBase Reference: 1-(2,4-difluorophenyl)piperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-difluorophenyl)piperidin-4-one(1016680-08-2)
• EPA Substance Registry System: 1-(2,4-difluorophenyl)piperidin-4-one(1016680-08-2)

Safety Data

• Hazardous Substances Data: 1016680-08-2(Hazardous Substances Data)

Usage

General Description

1-(2,4-difluorophenyl)piperidin-4-one is a chemical compound with the molecular formula C11H11F2NO. It is a piperidinone derivative, which is a class of compounds commonly used in medicine and as research chemicals. The presence of two fluorine atoms on the phenyl ring gives this compound unique properties and potential applications. It is often used as a building block in the synthesis of other organic compounds and may have potential pharmaceutical uses due to its structural features. The compound's precise properties and uses would depend on its specific synthesis and intended applications, and further research and development may be needed to fully understand its potential.

Upstream product

• 2265-93-2 2,4-difluoro-1-iodobenzene 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 348-57-2 2,4-difluorobromobenzene 
• 367-25-9 2,4-difluorophenylamine 
• 72548-31-3 1,5-Dichloropentan-3-ol 
• 263008-87-3 2'-O-[1-(2,4-Difluorophenyl)-4-methoxypiperidin-4-yl]uridine 

Downstream Products

• 263008-87-3 2'-O-[1-(2,4-Difluorophenyl)-4-methoxypiperidin-4-yl]uridine 
• 263008-80-6 1-(2,4-Difluorophenyl)-4-methoxy-1,2,5,6-tetrahydropyridine 

Relevant articles and documents

NOVEL TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The invention provides novel compounds having the general formula (I): wherein R1, R2, R3, Q, U,W, Z, X and Y are as described herein, compositions including the compounds and methods of using the compounds. These compounds are HbsAg inhibitors and are useful as medicaments for the treatment or prophylaxis of HBV infection.

Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides

The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.