101669-73-2

Upstream product

• 16695-14-0 Malonic acid monomethyl ester 
• 34101-07-0 (2S)-2-[N-(tert-butoxycarbonyl)amino]-1-imidazol-1-yl-3-phenylpropan-1-one 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 38330-80-2 monomethyl monopotassium malonate 
• 88815-92-3 1-(thio-t-Boc-α-aminophenylalanyl)-azacyclopentane 
• 96-32-2 bromoacetic acid methyl ester 
• 168774-14-9 (S)-1-(2'-t-butoxycarbonylamino-3'-phenylpropanoyl)-3,5-dimethylpyrazole 
• 118544-39-1 (Z)-(S)-4-tert-Butoxycarbonylamino-5-phenyl-3-pyrrolidin-1-yl-pent-2-enoic acid methyl ester 

Downstream Products

• 101669-80-1 methyl (3S,4S)-N-tert-butoxycarbonyl-4-amino-3-hydroxy-5-phenylpentanoate 
• 101669-81-2 (3R,4S)-4-<(tert-butoxycarbonyl)amino>-3-hydroxy-5-phenylpentanoic acid methyl ester 

Relevant academic research and scientific papers

COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS

The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.

DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA

Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions co

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4- hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates ar

The Reformatsky Reaction of 1-Acyl-3,5-dimethylpyrazoles. A Convenient Preparation of 4-Amino-3-oxoalkanoic Acid Derivatives

The conversion of N-acylpyrazoles into β-keto esters was accomplished efficiently by the treatment with α-bromo esters and zinc dust.Using this Reformatsky reaction of N-acylpyrazoles, 4-(protected amino)-3-oxoalkanoic acid derivatives were conveniently prepared as the key intermediates in the synthesis of statines.

Decarboxylative Carbon Acylation of Malonates with Aminoacylimidazoles Mediated by Lewis Acids

Various N-protected aminoacylimidazoles undergo decarboxylative carbon acylation with sodium or potassium monomethylmalonate in THF in the presence of MgCl2, CoCl2 or MnCl2 to give dipeptide analogues (3) in 45-82percent isolated yield.Amino ketoester (3e) undergoes intramolecular cyclization induced by diisopropylethylamine and anhydrous magnesium chloride to trisubstituted tetramic acid (4).

CARBOXYL-MODIFIED AMINO ACIDS AND PEPTIDES: I) AN EFFICIENT METHOD FOR THE SYNTHESIS OF MONOFUNCTIONALIZED ENAMINES AND MONOFUNCTIONALIZED METHYL KETONE DERIVATIVES FROM THIOAMIDES VIA EPISULFIDES AND THIOIMINIUM SALTS

Thioamides 4 were transformed by two convenient routes to various functionalized enamines 7 containing different electron-withdrawing groups E which on subsequent hydrolysis gave the corresponding methyl ketone derivatives 8.Application of this methodology to obtain modified dipeptides at the carboxyl end, the determination of stereochemistry and the degree of racemization are discussed.