1016867-30-3

Basic information

• Product Name: C₁₃H₁₅NO₂
• Synonyms: C₁₃H₁₅NO₂
• CAS NO: 1016867-30-3
• Molecular Weight: 217.268
• Mol File: 1016867-30-3.mol

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₅NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₅NO₂(1016867-30-3)
• EPA Substance Registry System: C₁₃H₁₅NO₂(1016867-30-3)

Safety Data

• Hazardous Substances Data: 1016867-30-3(Hazardous Substances Data)

Upstream product

• 685873-88-5 4-cyclopentyloxy-3-hydroxybenzaldehyde 

Downstream Products

• 1312793-87-5 tert-butyl 4-(3-(4-cyclopentyloxy-3-methoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate 
• 1016821-23-0 C₁₃H₁₈N₂O₃ 
• 1312793-94-4 3-(4-cyclopentyloxy-3-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole 

Relevant articles and documents

Design and Synthesis of 3,5-Disubstituted-1,2,4-Oxadiazoles as Potent Inhibitors of Phosphodiesterase4B2

A series of 3,5-disubstituted-1,2,4-oxadiazoles has been prepared and evaluated for phosphodiesterase inhibition (PDE4B2). Among the prepared 3,5-disubstituted-1,2,4-oxadiazoles, compound 9a is the most potent inhibitor (PDE4B2 IC50=5.28μm). Structure-activity relationship studies of 3,5-disubstituted-1,2,4-oxadiazoles revealed that substituents 3-cyclopentyloxy-4-methoxyphenyl group at 3-position and cyclic ring bearing heteroatoms at 5-position are important for activity. Molecular modeling study of the 3,5-disubstituted-1,2,4-oxadiazoles with PDE4B has shown similar interactions of 3-cyclopentyloxy-4-methoxyphenyl group; however, heteroatom ring is slightly deviating when compared to Piclamilast. 3-(3-Cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole (9a) exhibited good analgesic and antiinflammatory activities in formalin-induced pain in mice and carrageenan-induced paw edema model in rat.