101694-74-0

Basic information

• Product Name: 2α-bromo-4-O-tetrahydropyranylpicropodophyllotoxin
• Synonyms: 2α-bromo-4-O-tetrahydropyranylpicropodophyllotoxin
• CAS NO: 101694-74-0
• Molecular Weight: 577.426
• Mol File: 101694-74-0.mol

Chemical Properties

• CAS DataBase Reference: 2α-bromo-4-O-tetrahydropyranylpicropodophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: 2α-bromo-4-O-tetrahydropyranylpicropodophyllotoxin(101694-74-0)
• EPA Substance Registry System: 2α-bromo-4-O-tetrahydropyranylpicropodophyllotoxin(101694-74-0)

Safety Data

• Hazardous Substances Data: 101694-74-0(Hazardous Substances Data)

Upstream product

• 62318-97-2 4-O-tetrahydropyran-2-ylpodophyllotoxin 

Downstream Products

• 1311143-46-0 C₂₅H₂₇BrO₉ 
• 1311143-47-1 C₂₅H₂₇BrO₈ 
• 1311143-48-2 C₂₅H₂₇BrO₈ 
• 1311143-49-3 C₂₆H₂₉BrO₈ 
• 1311143-50-6 C₂₆H₂₉BrO₈ 
• 1311143-51-7 C₃₀H₃₇BrO₈ 
• 1311143-52-8 C₃₀H₃₇BrO₈ 
• 1311143-53-9 C₂₈H₃₁BrO₈ 
• 1311143-45-9 C₂₄H₂₅BrO₈ 
• 1311143-33-5 4α-n-butanoyloxy-2α-bromopicropodophyllotoxin 
• 1311143-44-8 C₂₃H₂₃BrO₈ 
• 1311143-39-1 C₃₀H₂₇BrO₉ 
• 1311143-38-0 C₂₉H₂₄BrNO₁₁ 
• 1311143-37-9 C₃₀H₂₇BrO₉ 

Relevant articles and documents

Stereoselective synthesis of 4α-acyloxy-2α/β- bromopodophyllotoxin derivatives as insecticidal agents

To find new natural products-based insecticidal agents, and substantially extend our previous work, we have designed and stereoselectively synthesized 4α-acyloxy-2α/β-bromopodophyllotoxin derivatives from podophyllotoxin. Interestingly, 4α-acyloxy-2α- bro

Stereoselective synthesis of 4α-Alkyloxy-2-α/β- bromopodophyllotoxin derivatives as insecticidal agents

Interesting insecticides: 4α-Alkyloxy-2α/β- bromopodophyllotoxin derivatives were readily prepared with excellent stereoselectivity due to intramolecular steric effects (see scheme). The ratio of two stereoisomers, 2α/β-bromo-4-O- tetrahydropyranylpodophyllotoxin, could be well controlled by the reaction temperature. Copyright

Preparation of 2-Substituted Podophyllotoxin Derivatives

A series of 2-substituted podophyllotoxin derivatives, including 2-methyl-, 2-chloro-, 2-hydroxy-, and 2-bromopodophyllotoxin, were prepared, in order to determine whether nonenolizable podophyllotoxins had enhanced in vivo activity against P388 and L1210 tumor cells.Significant activity against P388 (T/C 156, 40 mg/kg) was observed for 2-chloropodophyllotoxin; under similar conditions, podophyllotoxin was toxic.The corresponding 2-picro isomers were formed as byproducts in the above reactions and were, when tested, inactive against tumors at similar concentrations.An attempt to prepare 2-fluoropodophyllotoxin by reacting podophyllotoxin 4-O-THP enolate with FClO3 resulted in a violent explosion, causing serious injury.Extreme caution should be taken when reacting enolates with FClO3.