1016975-28-2

Upstream product

• 1016975-27-1 tert-butyl 4-oxo-3-phenyl-2-thioxo-1,3,4, 5,7,8-hexahydropyrido[4,3-d]pyrimidine-6(2H)-carboxylate 
• 74-88-4 methyl iodide 

Downstream Products

• 1016975-29-3 tert-butyl 2-(methanesulfinyl)-4-oxo-3-phenyl-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carboxylate 
• 1016975-38-4 2-(methylthio)-3-phenyl-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

COMPOUND HAVING BICYCLIC PYRIMIDINE STRUCTURE AND PHARMACEUTICAL COMPOSITION COMPRISING THE COMPOUND

The present invention relates to a bicyclic pyrimidine compound of the following formula (I) or a salt thereof. wherein R1 is lower alkyl, cyclic lower alkyl. etc.; R2 is H, lower alkyl, lower alkenyl, etc.; R3 is H, lower alkyl, lower alkenyl, etc.; X is O, S or -N(R4)-; R4 is H or lower alkyl; or R2 and R4 may combine each other to form cyclic amino; Y is amido, keto, sulfonyl, etc.; R5 is H or lower alkyl; Z is O or S; m and n are 1 or 2. Said compound (I) or a salt thereof have MGAT inhibitory activity, and are useful as an agent for treatment or prophylaxis of adiposity, metabolic syndromes, hyperlipidemia, hyper neutral lipemia, hyper VLDL-mia, hyper fatty acidemia, diabetes mellitus, arteriosclerosis.