1016987-49-7Relevant articles and documents
β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 1. Design, synthesis, and lead identification
Yang, Shyh-Ming,Scannevin, Robert H.,Wang, Bingbing,Burke, Sharon L.,Wilson, Lawrence J.,Karnachi, Prabha,Rhodes, Kenneth J.,Lagu, Bharat,Murray, William V.
, p. 1135 - 1139 (2008/12/22)
A new series of β-N-biaryl ether sulfonamide hydroxamates as novel gelatinase inhibitors is described. These compounds exhibit good potency for MMP-2 and MMP-9 without inhibiting MMP-1. The structure-activity relationships (SAR) reveal the biaryl ether ty
